Showing papers in "Journal of Neuroscience Methods in 1999"

TL;DR: It is demonstrated that this device is capable of maintaining cell survival, and that the electrodes can both record and stimulate electrical activity in individual cells with no crosstalk between channels.

TL;DR: This paper illustrates the use of the recently introduced method of partial directed coherence in approaching how interactions among neural structures change over short time spans that characterize well defined behavioral states.

TL;DR: A new planar multielectrode array (the MED probe) and its electronics which perform electrophysiological studies on acute hippocampal slices and a spatial distribution of long-term potentiation was studied using the MED system.

TL;DR: A new experimental facility has been developed to allow neural recordings in a monkey while it makes movements with a mechanical linkage attached to its arm, and preliminary results illustrate the ability of a monkey to perform a variety of multi-joint motor tasks under various static and dynamic loads.

TL;DR: This method was found to enhance immunolabeling in glutaraldehyde-fixed tissue that had been prepared for ultrastructural examination, without having a deleterious effect on the ultrastructure.

TL;DR: The cell biology underlying the sorting of synaptic vesicle proteins, trafficking of vesicles to terminals, and the development of presynaptic specializations is now more amenable to forward genetic analysis using these synaptic markers.

TL;DR: The experiments in behaving animals show how pharmacological inactivation is an effective analytical tool for dissecting the differential functional contributions of subcortical and cortical forelimb representations to limb movement control.

TL;DR: A very adaptable reversible inactivation technique for the behavioral or electrophysiological analysis of neural circuits, which provides great flexibility of experimental protocols, permits double and triple functional dissociations to be made, and strengthens experimental design considerably.

TL;DR: This review considers the different forms of reversible deactivation and how they differ from each other and from more conventional permanent deactivation methods.

TL;DR: The design and validation of a 100-channel PC-based system that can be used with arrays of extracellular electrodes such as the Utah Electrode Array is discussed, which performs online detection and storage of the spike waveforms for offline classification.

TL;DR: This study critically examines changes in synaptic morphology induced by microdialysis in rat striatum and indicates swollen processes up to 1.4 mm from the probe tract suggest intracellular chemical disruption.

TL;DR: PCA provides a powerful set of tools for selectively measuring neural ensemble activity within multiple functionally significant 'dimensions' of information processing, and redefines the 'neuron' as an entity which contributes portions of its variance to processing not one, but several tasks.

TL;DR: The data suggest that the flat surface and opaque properties of the customized platform enable accurate, reliable and repeatable measurements of ipsilateral and contralateral paw withdrawal threshold using von Frey hairs in normal and nerve-injured rats.

TL;DR: Since there are currently only a few tasks available to definitively test cognitive performance in mice, the circular platform task offers a versatile, multiple-measure option with numerous advantages and should be most useful in providing a sensitive evaluation of cognition in mice.

TL;DR: A method to estimate the neuronal firing rate from single-trial spike trains, based on convolution of the spike train with a fixed kernel function, is presented and rules for the optimized use and performance of the kernel method are derived.

TL;DR: It is concluded that the microporation of macromolecules is a versatile approach to investigate signaling, secretion, and other processes in CNS neurons.

TL;DR: An exposed hindbrain/spinal cord preparation in the curarized zebrafish embryo and larva is devised that permits intracellular labeling and patch clamp recording from individually identified sensory neurons, motoneurons and interneurons in vivo.

TL;DR: A general framework that encompasses both linear and non-linear modelling of neurophysiological time series data by means of Local Linear Non-linear Autoregressive models (LLNAR) is described and a new test forNon-linearity of time series and for non- linearity of directedness of neural interactions based on LLNAR is presented.

TL;DR: Methods to permit recordings in awake behaving monkeys using the 'Eckhorn' 16 electrode microdrive are described and a novel technique for correcting for non-stationarity in unit firing is discussed.

TL;DR: The results of this study indicate that age, verbal intelligence and motor practice should be considered when evaluating the effects of drug-treatment or psychiatric illness upon hand-movement in patients.

TL;DR: Cardiac parasympathetic stimulation can be achieved by positioning a catheter in the neurovascular bundle in the neck adjacent to the vagus nerve with resultant effects on cardiac electrophysiology.

TL;DR: A new approach is presented, the 'multiple shift' method (MS), which overcomes the need for binning and treats the data in their ( original) high time resolution (typically 1 ms, or better) and enhances the sensitivity for coincidences with temporal jitter.

TL;DR: An experiment is reviewed in which the representation of the direction of goal-directed arm movements in motor and premotor cortex is studied when prior and current information about upcoming movement tasks are integrated.

TL;DR: This method uses commercially available supplies and reproducible procedures to maintain healthy retinas with normal architecture for 4 weeks in vitro and can be used with both normal and retinal degeneration retinas to study of the role of various factors in photoreceptor degeneration in retinal cell fate determination and development.

TL;DR: An easy and inexpensive method for protecting the external portion of the catheter that enhances catheter viability beyond 14 days after catheter implantation while also maintaining a low injection volume is developed.

TL;DR: This paper uses multiple tetrode recordings from the hippocampus of the freely behaving rat to show that the action potential amplitude of a given cell can vary in a systematic and activity dependent manner over behaviorally relevant time scales.

TL;DR: Practical advice is provided on the choice of drug, means of delivering drugs, strategies for evaluating the action of injected drugs, and the application of this method to experiments with awake animals on reversible inactivation of subcortical targets.

TL;DR: Rat sleep is characterized by the absence of consensus about numerous elements constituting the sleep-wake staging systems used to build a hypnogram, and can be viewed as a representative of the effervescence of research in the field of sleep, and as a catalyst for new ideas.

TL;DR: AB offers a rapid objective measure of OL viability in primary culture and is a valid means to quantify OL death.

TL;DR: Data from populations of neurons recorded in the motor cortex of rats trained to perform a reaction-time task suggested that behaviorally relevant information is represented in correlated neuronal firing and can be best detected when higher-order correlations between neurons are taken into account.