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Yun Qian
Researcher at Sir Run Run Shaw Hospital
Publications - 27
Citations - 836
Yun Qian is an academic researcher from Sir Run Run Shaw Hospital. The author has contributed to research in topics: Cancer & Apoptosis. The author has an hindex of 12, co-authored 24 publications receiving 543 citations. Previous affiliations of Yun Qian include The Chinese University of Hong Kong & Zhejiang University.
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Journal ArticleDOI
Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
TL;DR: The recent discoveries linking epigenetics and metabolism and their underlying roles in tumorigenesis are summarized; and the promising molecular targets are highlighted, with an update on the development of small molecule or biologic inhibitors against these abnormalities in cancer.
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SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate
Chi Chun Wong,Yun Qian,Yun Qian,Xiaona Li,Jiaying Xu,Wei Kang,Joanna H.M. Tong,Ka Fai To,Ye Jin,Weilin Li,Huarong Chen,Minnie Y.Y. Go,Jian-Lin Wu,Ka-Wing Cheng,Simon S.M. Ng,Joseph J.Y. Sung,Zongwei Cai,Jun Yu +17 more
TL;DR: Levels of SLC25A22 messenger RNA and protein were increased in colorectal tumor tissues compared with matched nontumor colon tissues and increased protein levels were associated with shorter survival times of patients, indicating that oxaloacetate is required for cell survival.
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Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications.
TL;DR: This review summarized the recent discoveries involving metabolism and tumor metastasis, and emphasized the promising molecular targets, with an update on the development of small molecule or biologic inhibitors against these aberrant situations in cancer.
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In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance
Chi Chun Wong,Jiaying Xu,Xiqing Bian,Jian-Lin Wu,Wei Kang,Yun Qian,Weilin Li,Huarong Chen,Hongyan Gou,Dabin Liu,Simson Tsz Yat Luk,Qiming Zhou,Fenfen Ji,Lam-Shing Chan,Senji Shirasawa,Joseph J.Y. Sung,Jun Yu +16 more
TL;DR: This work investigated whether mutant KRAS-mediated glutaminolysis affects the epigenomes and activities of colorectal cancer (CRC) cells, and found CRC cells that express activated KRAS required glutamine for survival, and rapidly incorporated it into the tricarboxylic cycle (glutaminoleysis); this process required SLC25A22.
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A retrospective study of pyogenic liver abscess focusing on Klebsiella pneumoniae as a primary pathogen in China from 1994 to 2015.
Yun Qian,Chi Chun Wong,Sanchuan Lai,Huarong Chen,Xingkang He,Leimin Sun,Jiaguo Wu,Jiancang Zhou,Jun Yu,Weili Liu,Daoyang Zhou,Jianmin Si +11 more
TL;DR: Patients with KP-PLA had higher susceptibility to septic metastatic infection at distant sites compared to those with non-KP-PLA, and Klebsiella pneumoniae is the predominant pathogen of PLA in mainland China.