Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications.
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TLDR
This review summarized the recent discoveries involving metabolism and tumor metastasis, and emphasized the promising molecular targets, with an update on the development of small molecule or biologic inhibitors against these aberrant situations in cancer.Abstract:
Tumor metastasis is the major cause of mortality from cancer. Metabolic rewiring and the metastatic cascade are highly intertwined, co-operating to promote multiple steps of cancer metastasis. Metabolites generated by cancer cells influence the metastatic cascade, encompassing epithelial-mesenchymal transition (EMT), survival of cancer cells in circulation, and metastatic colonization at distant sites. A variety of molecular mechanisms underlie the prometastatic effect of tumor-derived metabolites, such as epigenetic deregulation, induction of matrix metalloproteinases (MMPs), promotion of cancer stemness, and alleviation of oxidative stress. Conversely, metastatic signaling regulates expression and activity of rate-limiting metabolic enzymes to generate prometastatic metabolites thereby reinforcing the metastasis cascade. Understanding the complex interplay between metabolism and metastasis could unravel novel molecular targets, whose intervention could lead to improvements in the treatment of cancer. In this review, we summarized the recent discoveries involving metabolism and tumor metastasis, and emphasized the promising molecular targets, with an update on the development of small molecule or biologic inhibitors against these aberrant situations in cancer.read more
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The gut microbial metabolite formate exacerbates colorectal cancer progression
Dominik Ternes,Mina Tsenkova,Vitaly I. Pozdeev,Marianne Meyers,E. Koncina,Sura Atatri,Martine Schmitz,Jessica Karta,Maryse Schmoetten,Almut Heinken,Fabien Rodriguez,Catherine Delbrouck,Anthoula Gaigneaux,Aurélien Ginolhac,Tam T.D. Nguyen,Léa Grandmougin,Audrey Frachet-Bour,Camille Martin-Gallausiaux,Maria Pires Pacheco,Lorie Neuberger-Castillo,Paulo Miranda,Nikolaus Zuegel,J Y Ferrand,Manon Gantenbein,Thomas Sauter,Daniel J. Slade,Ines Thiele,Johannes Meiser,Serge Haan,Paul Wilmes,Elisabeth Letellier +30 more
TL;DR: In this article , formate, a metabolite produced by the colorectal cancer associated bacterium Fusobacterium nucleatum, was shown to promote CRC development, and the authors identified formate as a gut derived oncometabolite that is relevant for CRC progression.
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.
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Edible fungal polysaccharides, the gut microbiota, and host health.
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