Yun Zhou

TL;DR: It is shown that without forming an atomically structured channel, four-monomer-based random heteropolymers (RHPs) 14 can mimic membrane proteins and exhibit selective proton transport across lipid bilayers at a rate similar to those of natural proton channels.

TL;DR: A microfluidic platform that integrates measurements of invasive motility and protein expression for single cells, which is used to scrutinize human glioblastoma tumor-initiating cells (TICs) and identifies protein-protein correlations within single TICs, which would be obscured with population-based assays.

TL;DR: Cobolt as mentioned in this paper uses multimodal variational autoencoder (MVAE) to integrate multi-modality platforms with single-cell platforms by jointly analyzing a SNARE-seq dataset, a singlecell gene expression dataset, and a single cell chromatin accessibility dataset.

TL;DR: GeneFishing is described, a semisupervised computational approach to reconstruct context-specific portraits of biological processes by leveraging gene–gene coexpression information that incorporates multiple high-dimensional statistical ideas, including dimensionality reduction, clustering, subsampling, and results aggregation, to produce robust results.

TL;DR: In this paper, a microarrayed, differential detergent fractionation was introduced to simultaneously detect protein complexes in hundreds of individual cells, and the effect of non-chemical stress on cellular heterogeneity of F-actin was investigated.