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Yunan Zhao
Researcher at Nanjing University of Chinese Medicine
Publications - 18
Citations - 192
Yunan Zhao is an academic researcher from Nanjing University of Chinese Medicine. The author has contributed to research in topics: Ginseng & Ginsenoside. The author has an hindex of 8, co-authored 12 publications receiving 148 citations.
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Chronic corticosterone exposure reduces hippocampal astrocyte structural plasticity and induces hippocampal atrophy in mice.
TL;DR: The reduction in the hippocampal astrocyte structural plasticity may represent the mechanism by which chronic CORT treatment causes hippocampal atrophy and depression-like behavior in male mice.
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Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3β-CREB Signaling Pathway
TL;DR: The findings imply that the effect of GTS on corticosterone-induced depression-like behavior may be mediated partly through interfering with hippocampal GSK-3β-CREB signaling pathway and reversing decrease of some plasticity-related proteins.
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Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam.
TL;DR: The findings suggest that the repeated CORT injection paradigm produces the astrocytic alterations similar to those in MDD and can serve as a useful mouse model to screen antidepressants meant to targetAstrocytes.
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Protein target identification of ginsenosides in skeletal muscle tissues: discovery of natural small-molecule activators of muscle-type creatine kinase
Feiyan Chen,Kexuan Zhu,Lin Chen,Liufeng Ouyang,Cuihua Chen,Ling Gu,Yucui Jiang,Zhongli Wang,Zixuan Lin,Qiang Zhang,Xiao Shao,Jianguo Dai,Yunan Zhao +12 more
TL;DR: Results suggest a cellular target and an initiating molecular event by which ginseng reduces fatigue and indicate PPD as a small molecular activator of CK-MM, which can help in further developing better CK- MM activators based on the dammarane-type triterpenoid structure.
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The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3β.
TL;DR: The results showed that GTS treatments relieved depression‐like behavior without altering the elevated serum corticosterone levels and raised the down‐regulated levels of hippocampal glycogen synthase kinase‐3β inhibitory phosphorylation, confirming the antidepressant effect of GTS in the cortic testosterone‐induced mouse depression model.