Yung Lyou

TL;DR: It is concluded that replication profiles are cell-type specific, and changes in these profiles reveal chromosome segments that undergo large changes in organization during differentiation, a novel characteristic of the pluripotent state.

TL;DR: In this article , a bifidogenic live bacterial product (CBM588) was proposed to augment the response to checkpoint inhibitors through modulation of the gut microbiome, and the results showed that CBM588 appeared to enhance the clinical outcome in patients with metastatic renal cell carcinoma treated with nivolumab-ipilimumab.

TL;DR: It is suggested that Maturin functions during primary neurogenesis and is required for the proneural pathway to regulate neural differentiation.

TL;DR: In this paper , the genomic signatures of patients with metastatic renal cell carcinoma (mRCC) who underwent SBRT for oligoprogressive disease were identified, and the median DOT(P) and DOT(S) were 15.1 and 18.3 mo, respectively, with a median DOT (S)/DOT (P) ratio of 1.4.

TL;DR: While vaccine-associated concerns were observed, most patients with genitourinary cancers were willing to receive the vaccine and differing strategies could be considered to enhance patient education on the utility of vaccination in the setting of cancer and beyond.