Tim M. Townes

TL;DR: This work identifies the transcription factor ATF4 as a critical substrate of RSK2 that is required for the timely onset of osteoblast differentiation, for terminal differentiation of osteoblasts, and for osteoplast-specific gene expression and indicates that lack of ATF4 phosphorylation by R SK2 may contribute to the skeletal phenotype of CLS.

TL;DR: It is concluded that replication profiles are cell-type specific, and changes in these profiles reveal chromosome segments that undergo large changes in organization during differentiation, a novel characteristic of the pluripotent state.

TL;DR: Human beta‐globin protein was detectable in mature erythrocytes from progeny of one of these mice and the frequency and extent of expression was severely depressed when the procaryotic vector DNA was not removed prior to microinjection.

TL;DR: Data reveal that episodes of intrahepatic hypoxia-reoxygenation associated with SCD can induce the release of XO into the circulation from the liver.

TL;DR: Control knockdown of KLF1 in adult erythroid progenitors may provide a method to activate fetal hemoglobin expression in individuals with β-thalassemia or sickle cell disease.