Yunying Shi

TL;DR: This study indicated that development of RA is associated with peripheral Th17/Treg imbalance and characterized by a proinflammatory cytokine microenvironment, which supports continuing generation of Th17 cells.

TL;DR: Tacrolimus (Tac) is effective in preventing acute rejection but has considerable toxicity and inter-individual variability in pharmacokinetics and pharmacodynamics, which may help to minimize different outcomes amongst transplant recipients by personalizing immunosuppression.

TL;DR: Traditional TDM, perhaps following pre-emptive genotyping for Tac-metabolizing enzymes, must suffice for a few years before these strategies can be implemented in clinical practice.

TL;DR: Using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and DNA sequencing techniques, the genotype and allele distributions of two single nucleotide polymorphisms (SNP) loci in the promoter region of IL-10 and IL-18 genes are analyzed, providing new insight for the polymorphism ofIL-10 gene in the pathogenesis of RA.

TL;DR: The results provided the first evidence that the SNP rs3746444 in pre-miR-499 could affect the inflammatory reaction in patients with RA, and might contribute to the clinical assessment of inflammatory activity, which in turn may influence therapeutic decision making.