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Yurij Ionov
Researcher at Roswell Park Cancer Institute
Publications - 26
Citations - 5964
Yurij Ionov is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Carcinogenesis & Microsatellite Mutator Phenotype. The author has an hindex of 17, co-authored 26 publications receiving 5769 citations. Previous affiliations of Yurij Ionov include Sanford-Burnham Institute for Medical Research & Yale University.
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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
TL;DR: It is shown that 12 per cent of colorectal carcinomas carry somatic deletions in poly(dA . dT) sequences and other simple repeats, and it is concluded that these mutations reflect a previously undescribed form of carcinogenesis in the colon mediated by a mutation in a DNA replication factor resulting in reduced fidelity for replication or repair (a 'mutator mutation').
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Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
Nicholas Rampino,Hiroyuki Yamamoto,Yurij Ionov,Yan Li,Hisako Sawai,John C. Reed,Manuel Perucho +6 more
TL;DR: The results suggest that inactivating BAX mutations are selected for during the progression of colorectal MMP+ tumors and that the wild-type BAX gene plays a suppressor role in a p53-independent pathway for coloreCTal carcinogenesis.
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Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation.
TL;DR: In vivo and in vitro results show that the genomic instability persists after transformation and that microsatellite mutations accumulate as consecutive somatic slippage events of a single or a few repeated units.
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Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution.
TL;DR: It is shown that inactivation of the wild-type BAX allele by de novo frameshift mutations confers a strong advantage during tumor clonal evolution, and this results support the interpretation that BAX inactivation contributes to tumor progression by providing a survival advantage.
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Prognostic significance of apoptosis regulators in breast cancer.
Stan Krajewski,M Krajewska,B C Turner,C Pratt,B Howard,Juan M. Zapata,V Frenkel,Susan J. Robertson,Yurij Ionov,H Yamamoto,Manuel Perucho,Shinichi Takayama,John C. Reed +12 more
TL;DR: Attempts thus far to explore the expression of several Bcl-2 family proteins, caspase-3, and BAG-1 in primary breast cancer specimens and breast cancer cell lines are summarized.