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Yuriy K. Bashmakov
Researcher at University of Texas Southwestern Medical Center
Publications - 42
Citations - 6479
Yuriy K. Bashmakov is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Insulin & Sterol regulatory element-binding protein. The author has an hindex of 20, co-authored 42 publications receiving 6153 citations.
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Journal ArticleDOI
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
Iichiro Shimomura,Morihiro Matsuda,Robert E. Hammer,Yuriy K. Bashmakov,Michael S. Brown,Joseph L. Goldstein +5 more
TL;DR: In this paper, the authors show that chronic hyperinsulinemia downregulates the mRNA for IRS-2, an essential component of the insulin-signaling pathway in liver, thereby producing insulin resistance.
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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
Shirya Rashid,David E. Curtis,Rita Garuti,Norma H. Anderson,Yuriy K. Bashmakov,Y. K. Ho,Robert E. Hammer,Young Ah Moon,Jay D. Horton +8 more
TL;DR: It is demonstrated that PCSK9 regulates the amount of LDLR protein in liver and suggested that inhibitors of PCSK 9 may act synergistically with statins to enhance LDLRs and reduce plasma cholesterol.
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Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
Iichiro Shimomura,Robert E. Hammer,James A. Richardson,Shinji Ikemoto,Yuriy K. Bashmakov,Joseph L. Goldstein,Michael S. Brown +6 more
TL;DR: Transgenic mice that overexpress nSREBP-1c in adipose tissue under the control of the adipocyte-specific aP2 enhancer/promoter exhibit many of the features of congenital generalized lipodystrophy (CGL), an autosomal recessive disorder in humans.
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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
Iichiro Shimomura,Yuriy K. Bashmakov,Shinji Ikemoto,Jay D. Horton,Michael S. Brown,Joseph L. Goldstein +5 more
TL;DR: In vivo studies suggest that insulin may stimulate lipid synthesis in the liver by selectively inducing transcription of the SREBP-1c gene, which is encoded by a separate gene.
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Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus
TL;DR: It is suggested that increased levels of nuclear SREBP-1c contribute to the elevated rates of hepatic fatty acid synthesis that leads to steatosis in diabetic mice.