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Yuriy Kirichok
Researcher at University of California, San Francisco
Publications - 42
Citations - 6215
Yuriy Kirichok is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Sperm & Inner mitochondrial membrane. The author has an hindex of 22, co-authored 38 publications receiving 5328 citations. Previous affiliations of Yuriy Kirichok include University of California & Howard Hughes Medical Institute.
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Journal ArticleDOI
The mitochondrial calcium uniporter is a highly selective ion channel
TL;DR: By patch-clamping the inner mitochondrial membrane, it is concluded that the properties of the current mediated by this novel channel are those of the MCU, enabling high Ca2+ selectivity despite relatively low cytoplasmic Ca 2+ concentrations.
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Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria
TL;DR: It is shown that UCP1 is an LCFA anion/H(+) symporter that effectively operates as an H(+) carrier activated by LCFA, and a similar LCFA-dependent mechanism of transmembrane H(+, transport may be employed by other SLC25 members and be responsible for mitochondrial uncoupling and regulation of metabolic efficiency in various tissues.
Journal ArticleDOI
Progesterone activates the principal Ca2+ channel of human sperm.
TL;DR: It is found that nanomolar concentrations of progesterone dramatically potentiate CatSper, a pH-dependent Ca2+ channel of the sperm flagellum, which represents a promising target for the development of a new class of non-hormonal contraceptives.
Journal ArticleDOI
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
Huayu Qi,Magdalene M. Moran,Betsy Navarro,Jayhong A. Chong,Grigory Krapivinsky,Luba Krapivinsky,Yuriy Kirichok,I. Scott Ramsey,Timothy A. Quill,David E. Clapham +9 more
TL;DR: Direct protein interactions among CatSpers, the sperm specificity of these proteins, and loss of ICatSper in each of the four CatSper−/− mice indicate that CatSper are highly specialized flagellar proteins.
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Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel.
TL;DR: It is suggested that intracellular alkalinization potentiates CatSper current to increase intraflagellar calcium and induce sperm hyperactivation, and is identified as a component of the key flageLLar calcium channel.