M
Magdalene M. Moran
Researcher at Howard Hughes Medical Institute
Publications - 33
Citations - 5020
Magdalene M. Moran is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Transient receptor potential channel & TRPV1. The author has an hindex of 17, co-authored 33 publications receiving 4565 citations. Previous affiliations of Magdalene M. Moran include Harvard University.
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Journal ArticleDOI
TRPA1 mediates formalin-induced pain
Colleen Mcnamara,Josh Mandel-Brehm,Diana M. Bautista,Jan Siemens,Kari L. Deranian,Michael Zhao,Neil Hayward,Jayhong A. Chong,David Julius,Magdalene M. Moran,Christopher M. Fanger +10 more
TL;DR: It is shown that TRPA1 is the principal site of formalin's pain-producing action in vivo, and that activation of this excitatory channel underlies the physiological and behavioral responses associated with this model of pain hypersensitivity.
Journal ArticleDOI
TRPV3 is a calcium-permeable temperature-sensitive cation channel
Haoxing Xu,I. Scott Ramsey,Suhas A. Kotecha,Magdalene M. Moran,Jayhong A. Chong,Deborah Lawson,Pei Ge,Jeremiah Lilly,Inmaculada Silos-Santiago,Yu Xie,Peter S. DiStefano,Rory A. J. Curtis,David E. Clapham +12 more
TL;DR: It is proposed that hTRPV3 is thermosensitive in the physiological range of temperatures between TRPM8 and TRPV1.
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A voltage-gated proton-selective channel lacking the pore domain
TL;DR: The data presented here identify HV1 as a long-sought voltage-gated H+ channel and establish Hv1 as the founding member of a family of mammalian VSD proteins.
Journal ArticleDOI
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
Huayu Qi,Magdalene M. Moran,Betsy Navarro,Jayhong A. Chong,Grigory Krapivinsky,Luba Krapivinsky,Yuriy Kirichok,I. Scott Ramsey,Timothy A. Quill,David E. Clapham +9 more
TL;DR: Direct protein interactions among CatSpers, the sperm specificity of these proteins, and loss of ICatSper in each of the four CatSper−/− mice indicate that CatSper are highly specialized flagellar proteins.
Journal ArticleDOI
A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
Ana Isabel Caceres,Marian Brackmann,Maxwell D. Elia,Bret F. Bessac,Donato del Camino,Marc D'Amours,JoAnn S. Witek,Chistopher M. Fanger,Jayhong A. Chong,Neil Hayward,Robert J. Homer,Lauren Cohn,Xiaozhu Huang,Magdalene M. Moran,Sven-Eric Jordt +14 more
TL;DR: The data suggest that TRPA1 is a key integrator of interactions between the immune and nervous systems in the airways, driving asthmatic airway inflammation following inhaled allergen challenge, and may represent a promising pharmacological target for the treatment of asthma.