Yusra Rahman

TL;DR: In vitro experiments and in silico molecular docking studies concluded that CA binds to the minor groove of Ct-DNA, suggesting that hydrogen bonding and van der Waal's forces played major role in the binding process.

TL;DR: A series of biophysical experiments were performed to ascertain the binding mode between ticlopidine and calf thymus DNA and found the reaction to be endothermic and the parameters obtained were found to be consistent with those of known groove binders.

TL;DR: Thermodynamic parameters obtained from isothermal titration calorimetric studies suggest that the interaction of pirenzepine with Ct-DNA is enthalpically driven, and the role of electrostatic interaction in the binding of pirensepine to Ct- DNA cannot be precluded.

TL;DR: It is confirmed that the formation of the sulindac–Ct-DNA complex is spontaneous and enthalpy (ΔH < 0) driven, which is further supported by the consistent results obtained from the in silico molecular docking studies.

TL;DR: In this article, the average binding distance between BSA and pirenzepine was calculated based on the Forster's non-radiative energy transfer theory, and the effect of inclusion compound, β-cyclodextrin on pirenziepine-BSA interaction was studied.