Yutaka Shimada

TL;DR: It is suggested that Hachimi‐jio‐gan could prevent diabetic kidney damage by reducing renal oxidative injury and expression of fibronectin and TGF‐β1 proteins, which are all involved in the pathophysiology of diabetic nephropathy.

TL;DR: When incubated with RBC suspension, Choto-san extract (CSE) and Uncaria sinensis extract (USE) exhibited strong protection for RBC membrane against hemolysis induced by 2,2-azo-bis (2-amidinopropane) dihydrochloride (AAPH), an azo free-radical initiator.

TL;DR: The results suggest that IFN-γ is one candidate for cytokine-based therapy of cancer and that STAT1 activation might be involved in the apoptosis of esophageal SCC cells and in the terminal differentiation of normal squamous cells.

TL;DR: Yokukansan relieves mechanical allodynia in PSL mice by regulating the expression of IL-6 in astrocytes and/or microglia in the spinal cord, and the components of Atractylodis Lanceae Rhizoma, one of the constituent herbal medicines in yokukan, may play an important role in the regulation ofIL-6 expression and neuropathic pain control.

TL;DR: Using a high-performance liquid chromatographic method and mass spectrometry analysis, the absorption of orally administered procyanidin B-2 and procyanthine B-3 isolated from Cinnamonomi cortex is measured in rat plasma.