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Yutao Yan
Researcher at Emory University
Publications - 48
Citations - 2358
Yutao Yan is an academic researcher from Emory University. The author has contributed to research in topics: Colitis & Intestinal mucosa. The author has an hindex of 27, co-authored 48 publications receiving 2132 citations. Previous affiliations of Yutao Yan include Georgia State University.
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Journal ArticleDOI
Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis
Yutao Yan,Vasantha L. Kolachala,Guillaume Dalmasso,Hang T. Nguyen,Hamed Laroui,Shanthi V. Sitaraman,Didier Merlin +6 more
TL;DR: Experimental colitis induced by DSS is a good animal model to study the mechanisms underlying the pathogenesis and intervention against IBD, especially UC.
Journal ArticleDOI
Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model
Hamed Laroui,Guillaume Dalmasso,Hang Thi Thu Nguyen,Yutao Yan,Shanthi V. Sitaraman,Didier Merlin +5 more
TL;DR: Nanoparticles are a versatile drug delivery system that can overcome physiologic barriers and target anti-inflammatory agents such as the peptide KPV to inflamed areas.
Journal ArticleDOI
Microbiota Modulate Host Gene Expression via MicroRNAs
Guillaume Dalmasso,Hang Thi Thu Nguyen,Yutao Yan,Hamed Laroui,Moiz A. Charania,Saravanan Ayyadurai,Shanthi V. Sitaraman,Didier Merlin,Didier Merlin +8 more
TL;DR: It is demonstrated that microbiota modulate host microRNA expression, which could in turn regulate host gene expression.
Journal ArticleDOI
Functional TNFα gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon.
Hamed Laroui,Arianne L. Theiss,Yutao Yan,Guillaume Dalmasso,Hang T.T. Nguyen,Shanthi V. Sitaraman,Didier Merlin,Didier Merlin +7 more
TL;DR: It is demonstrated that TNFα siRNA/polyethyleneimine loaded into polylactide at an optimal concentration of 20 g/L nanoparticles covered with polyvinyl alcohol are efficiently taken up by inflamed macrophages and inhibit TNF α secretion by the macrophage.
Journal ArticleDOI
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Guillaume Dalmasso,Laetitia Charrier-Hisamuddin,Hang Thi Thu Nguyen,Yutao Yan,Shanthi V. Sitaraman,Didier Merlin +5 more
TL;DR: It is found that KPV acts via PepT1 expressed in immune and intestinal epithelial cells, and oral administration of KPV reduces the incidence of DSS- and TNBS-induced colitis indicated by a decrease in pro-inflammatory cytokine expression.