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Yuxing Zhao
Researcher at St. Vincent's Institute of Medical Research
Publications - 9
Citations - 378
Yuxing Zhao is an academic researcher from St. Vincent's Institute of Medical Research. The author has contributed to research in topics: Pancreatic islets & Proinflammatory cytokine. The author has an hindex of 8, co-authored 9 publications receiving 325 citations. Previous affiliations of Yuxing Zhao include St. Vincent's Health System.
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Journal ArticleDOI
The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
Jibran Ja Wali,Dieter Rondas,Mark D. McKenzie,Yuxing Zhao,Lorraine Elkerbout,Stacey Fynch,Esteban Nicolas Gurzov,Shizuo Akira,Chantal Mathieu,Thomas W.H. Kay,Lut Overbergh,Andreas Strasser,Helen E. Thomas +12 more
TL;DR: The data demonstrate that high concentrations of glucose induce ER and oxidative stress, which causes cell death mediated by Bim and Puma, which indicates that inhibition of BIM and Pum, or their inducers, may prevent beta-cell destruction in type 2 diabetes.
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Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation
TL;DR: It is found that robust STAT1 activation does not occur until 2–3 h after TLR engagement, and that GC suppression of STAT1 phosphorylation first manifests at this time, which may account for overall GC effectiveness in inflammation suppression in the clinically relevant time frame.
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Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.
Kate L. Graham,Robyn M. Sutherland,Robyn M. Sutherland,Stuart I. Mannering,Stuart I. Mannering,Yuxing Zhao,Jonathan Chee,Jonathan Chee,Balasubramanian Krishnamurthy,Balasubramanian Krishnamurthy,Helen E. Thomas,Helen E. Thomas,Andrew M. Lew,Andrew M. Lew,Thomas W.H. Kay,Thomas W.H. Kay +15 more
TL;DR: The pathogenic mechanisms utilized by the immune system to mediate destruction of the pancreatic beta-cells are outlined, and the islet is highlighted as both driver and target of the disease.
Journal ArticleDOI
NF-κB in type 1 diabetes.
TL;DR: The critical role of NF-κB in type 1 diabetes renders it a promising pharmaceutical target in the intervention of this disease and further understanding of the NF-σB pathway will have an important implication on the development of novel and safe therapeutic strategies.
Journal ArticleDOI
Mouse pancreatic beta cells express MHC class II and stimulate CD4+ T cells to proliferate
Yuxing Zhao,Nicholas A. Scott,Hong Sheng Quah,Balasubramanian Krishnamurthy,Francene Bond,Thomas Loudovaris,Stuart I. Mannering,Thomas W.H. Kay,Helen E. Thomas +8 more
TL;DR: It is indicated that MHC class II molecules may play an important role in beta‐cell interaction with CD4+ T cells in the development of type 1 diabetes.