S
Stuart I. Mannering
Researcher at St. Vincent's Institute of Medical Research
Publications - 78
Citations - 4352
Stuart I. Mannering is an academic researcher from St. Vincent's Institute of Medical Research. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 30, co-authored 76 publications receiving 3669 citations. Previous affiliations of Stuart I. Mannering include Walter and Eliza Hall Institute of Medical Research & Alfred Hospital.
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Journal ArticleDOI
Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease
Jason A. Tye-Din,Jessica Anne Stewart,James Dromey,Tim Beissbarth,David A. van Heel,Arthur S. Tatham,Kate Henderson,Stuart I. Mannering,Carmen Gianfrani,Derek P. Jewell,Adrian V. S. Hill,James McCluskey,Jamie Rossjohn,Robert P. Anderson,Robert P. Anderson +14 more
TL;DR: The discovery that a small number of peptides can elicit the disease in patients suggests that a similar approach may be successful in humans as well, and a detailed molecular understanding of the peptides driving the immune response in celiac disease is required.
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Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Thomas Delong,Timothy A. Wiles,Rocky L. Baker,Brenda Bradley,Gene Barbour,Richard Reisdorph,Michael Armstrong,Roger Powell,Nichole Reisdorph,Nitesh Kumar,Colleen M. Elso,Megan E DeNicola,Rita Bottino,Alvin C. Powers,David M. Harlan,Sally C. Kent,Stuart I. Mannering,Kathryn Haskins +17 more
TL;DR: It is found that diabetes-inducing CD4 T cell clones isolated from nonobese diabetic mice recognize epitopes formed by covalent cross-linking of proinsulin peptides to other peptides present in β cell secretory granules, which may explain how immune tolerance is broken in T1D.
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Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.
Diana Mittag,Anna I Proietto,Thomas Loudovaris,Stuart I. Mannering,David Vremec,Ken Shortman,Li Wu,Leonard C. Harrison +7 more
TL;DR: It is indicated that human blood DC closely resemble human spleen DC, and parallels between human and mouse DC subsets in phenotype and function are confirmed, but differences in transcription factor and TLR expression as well as functional properties are identified.
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Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society
Roberto Mallone,Stuart I. Mannering,Barbara Brooks-Worrell,Ivana Durinovic-Belló,Corrado M. Cilio,Florence Susan Wong,Nanette C. Schloot +6 more
TL;DR: Recommendations on processing blood samples for T cell assays are proposed and gaps in knowledge are identified, relevant not only for the analysis of T cell responses in autoimmune disease, but also in cancer and infectious disease, particularly in the context of clinical trials.
Journal ArticleDOI
The insulin A-chain epitope recognized by human T cells is posttranslationally modified.
Stuart I. Mannering,Leonard C. Harrison,Nicholas A. Williamson,Jessica S. Morris,Daniel J. Thearle,Kent P. Jensen,Thomas W.H. Kay,Jamie Rossjohn,Ben A. Falk,Gerald T. Nepom,Anthony W. Purcell +10 more
TL;DR: It is defined for the first time a novel posttranslational modification that is required for T cell recognition of the insulin A-chain in T1D.