European Association for Osseointegration; 19-22 February 2009, Pfaffikon, Switzerland; 2nd Consensus Conference

Effects of titanium surface topography on bone integration: a systematic review

Advancing dental implant surface technology--from micron- to nanotopography.

There is currently an unmet need for the supply of autologous, patient-specific stem cells for regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by the material/cell interface suggesting a unique strategy to manipulate stem cells in the absence of complex soluble chemistries or cellular reprogramming. However, so far the derivation and identification of surfaces that allow retention of multipotency of this key regenerative cell type have remained elusive. Adult stem cells spontaneously differentiate in culture, resulting in a rapid diminution of the multipotent cell population and their regenerative capacity. Here we identify a nanostructured surface that retains stem-cell phenotype and maintains stem-cell growth over eight weeks. Furthermore, the study implicates a role for small RNAs in repressing key cell signalling and metabolomic pathways, demonstrating the potential of surfaces as non-invasive tools with which to address the stem cell niche.

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jor.23075

Laser and electron-beam powder-bed additive manufacturing of metallic implants: A review on processes, materials and designs.

Engineering biocompatible implant surfaces

Surface treatments of titanium dental implants for rapid osseointegration

Osteoblastic cell behaviour on different titanium implant surfaces

https://www.hal.inserm.fr/inserm-00166069/document

The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial

Objectives: The surface properties of titanium dental implants are key parameters for rapid and intimate bone–implant contact. The osseointegration of four implant surfaces was studied in the femoral epiphyses of rabbits.

Material and methods: Titanium implants were either grit-blasted with alumina or biphasic calcium phosphate (BCP) ceramic particles, coated with a thin octacalcium phosphate (OCP) layer, or prepared by large-grit sand blasting and acid-etched (SLA). After 2 and 8 weeks of implantation, the bone-implant contact and bone growth inside the chambers were compared. Scanning electron microscopy (SEM) and profilometry showed distinct microtopographies.

Results: The alumina-Ti, BCP-Ti and OCP-Ti groups had similar average surface roughness in the 1–2 μm range whereas the SLA surface was significantly higher with a roughness averaging 4.5 μm. Concerning the osseointegration, the study demonstrated a significantly greater bone-to-implant contact for both the SLA and OCP-Ti surfaces as compared with the grit-blasted surfaces, alumina- and BCP-Ti at both 2 and 8 weeks of healing.

Conclusion: In this animal model, a biomimetic calcium phosphate coating gave similar osseointegration to the SLA surface. This biomimetic coating method may enhance the apposition of bone onto titanium dental implants.

Yves Amouriq

Papers

Surface treatments of titanium dental implants for rapid osseointegration

Osteoblastic cell behaviour on different titanium implant surfaces

The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial

Histomorphometric analysis of the osseointegration of four different implant surfaces in the femoral epiphyses of rabbits.

Osteoblastic cell behavior on nanostructured metal implants.