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Yves Gaudin
Researcher at Université Paris-Saclay
Publications - 67
Citations - 4940
Yves Gaudin is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Lipid bilayer fusion & Vesicular stomatitis virus. The author has an hindex of 36, co-authored 65 publications receiving 4443 citations. Previous affiliations of Yves Gaudin include Institut national de la recherche agronomique & Centre national de la recherche scientifique.
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Journal ArticleDOI
Crystal Structure of the Low-pH Form of the Vesicular Stomatitis Virus Glycoprotein G
TL;DR: The vesicular stomatitis virus has an atypical membrane fusion glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms at the virus surface, and is homologous to gB of herpesviruses, which raises important questions on viral evolution.
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Structure of the Prefusion Form of the Vesicular Stomatitis Virus Glycoprotein G
TL;DR: The structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G, and suggests a pathway for the conformational change.
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Functional Characterization of Negri Bodies (NBs) in Rabies Virus-Infected Cells: Evidence that NBs Are Sites of Viral Transcription and Replication
Xavier Lahaye,Aurore Vidy,Carole Pomier,Linda Obiang,Francis Harper,Yves Gaudin,Danielle Blondel +6 more
TL;DR: In situ fluorescent hybridization techniques show that all viral RNAs (genome, antigenome, and every mRNA) are located inside the inclusion bodies, and short-term RNA labeling in the presence of BrUTP strongly suggests that the NBLs are the sites where viral transcription and replication take place.
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Virus membrane fusion
TL;DR: The major principles of viral fusion are understood, but the structures of fusion protein intermediates and their mode of lipid bilayer interaction, the structures and functions of the membrane anchors and the number of fusion proteins required for fusion, necessitate further investigations.
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Rabies virus glycoprotein is a trimer
TL;DR: The oligomerization state of the rabies virus envelope glycoprotein (G protein) was determined using electron microscopy and sedimentation analysis of detergent solubilized G using CHAPS, which allowed its further separation from M1 and M2.