Z
Zaiming Tang
Researcher at University of Texas Southwestern Medical Center
Publications - 9
Citations - 574
Zaiming Tang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 3 publications receiving 473 citations. Previous affiliations of Zaiming Tang include Zhejiang University & University of California, Berkeley.
Papers
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Journal ArticleDOI
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites
Zaiming Tang,Mary Grace Lin,Timothy R. Stowe,She Chen,Muyuan Zhu,Tim Stearns,Brunella Franco,Qing Zhong +7 more
TL;DR: It is demonstrated that autophagic degradation of a ciliopathy protein, OFD1 (oral-facial-digital syndrome 1), at centriolar satellites promotes primary cilium biogenesis, defining a newly recognized role of autophagy in organelle biogenesis.
Journal ArticleDOI
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy
Weiliang Fan,Zaiming Tang,Zaiming Tang,Dandan Chen,Diana Moughon,Xiaojun Ding,She Chen,Muyuan Zhu,Qing Zhong +8 more
TL;DR: Keap1 is assigned a novel positive role in upregulating p62-mediated autophagic clearance of ubiquitin aggregates, and p62 serves as a bridge between Keap1 and ubiquit in aggregates and autophagosomes.
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Self-eating to remove cilia roadblock
TL;DR: It is found that the autophagosome membrane anchored protein LC3 interacts with OFD1 (oral-facial-digital syndrome 1) and removes it from the centriolar satellite upon serum starvation to initiate primary cilium biogenesis, suggesting an unexpected link among autophagy, ciliogenesis, cilopathy, and cancers.
Journal ArticleDOI
STING controls energy stress-induced autophagy and energy metabolism via STX17
Yue Rong,Shuang Zhang,Nilay Nandi,Zhe Wu,Linsen Li,Yang Liu,Yuehan Wei,Yueran Zhao,Weigang Yuan,Chuchu Zhou,Guanghua Xiao,Beth Levine,Nan Yan,Shan Mou,Liufu Deng,Zaiming Tang,Xiaoxia Liu,Helmut Kramer,Qing Zhong +18 more
TL;DR: A heretofore unexpected function of STING is demonstrated in energy stress-induced autophagy through spatial regulation of autophagic SNARE STX17, a SNARE that is essential for autophagosome biogenesis and autophosome-lysosome fusion.
Journal ArticleDOI
Cell cycle arrest induced by trichoplein depletion is independent of cilia assembly
TL;DR: It is shown that deletion of TCHP not only prevented the progression to the S phase but also resulted in cell cycle exit and entrance into G0 phase, and this study provides new insights into the function of T CHP incell cycle progression.