Z
Zeping Luo
Researcher at University of California, San Francisco
Publications - 9
Citations - 635
Zeping Luo is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: P-TEFb & RNA polymerase II. The author has an hindex of 8, co-authored 8 publications receiving 540 citations.
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Journal ArticleDOI
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
Dalibor Blazek,Jiri Kohoutek,Koen Bartholomeeusen,Eric B. Johansen,Petra Hulinkova,Zeping Luo,Peter Cimermancic,Jernej Ule,B. Matija Peterlin +8 more
TL;DR: It is concluded that through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability and the essential role of Cyck for organisms in vivo is further supported.
Journal ArticleDOI
Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.
Tristan Eifler,Wei Shao,Koen Bartholomeeusen,Koh Fujinaga,Stefanie Jäger,Stefanie Jäger,Jeffrey R. Johnson,Jeffrey R. Johnson,Zeping Luo,Nevan J. Krogan,Nevan J. Krogan,B. Matija Peterlin +11 more
TL;DR: An important role for CDK12 is described in the epidermal growth factor-induced c-FOS proto-oncogene expression in mammalian cells and this kinase plays an important role in cotranscriptional processing of c- FOS transcripts.
Journal ArticleDOI
Cyclin T2 is essential for mouse embryogenesis.
TL;DR: Visualizing β-galactosidase during mouse embryogenesis revealed that CycT2 is expressed abundantly during embryogenesis and throughout the organism in the adult, and this finding was reflected in the expression of CyCT2 in all adult tissues and organs.
Journal ArticleDOI
PKC phosphorylates HEXIM1 and regulates P-TEFb activity
TL;DR: It is demonstrated that protein kinase C (PKC) phosphorylates the serine at position158 (S158) in HEXIM1, indicating that the phosphorylation of H EXIM1 by PKC represents a major regulatory step of P-TEFb activity in cells.
Journal ArticleDOI
Moloney Leukemia Virus Type 10 Inhibits Reverse Transcription and Retrotransposition of Intracisternal A Particles
Chuanyi M. Lu,Zeping Luo,Stefanie Jäger,Nevan J. Krogan,Boris Matija Peterlin,Boris Matija Peterlin +5 more
TL;DR: By interfering with reverse transcription, MOV10 inhibits IAP RTP, and this inhibition is independent of P bodies.