J
Jeffrey R. Johnson
Researcher at University of California, San Francisco
Publications - 96
Citations - 8949
Jeffrey R. Johnson is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Gene & Ubiquitin ligase. The author has an hindex of 42, co-authored 96 publications receiving 7631 citations. Previous affiliations of Jeffrey R. Johnson include Scripps Research Institute & Gladstone Institutes.
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Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
Shashank Tripathi,Marie O. Pohl,Yingyao Zhou,Ariel Rodriguez-Frandsen,Guojun Wang,David A. Stein,Hong M. Moulton,Paul DeJesus,Jianwei Che,Lubbertus C. F. Mulder,Emilio Yángüez,Dario Andenmatten,Lars Pache,Balaji Manicassamy,Randy A. Albrecht,Maria G. Gonzalez,Quy T. Nguyen,Abraham L. Brass,Stephen J. Elledge,Stephen J. Elledge,Michael A. White,Sagi Shapira,Nir Hacohen,Alexander Karlas,Thomas F. Meyer,Michael Shales,Andre Gatorano,Jeffrey R. Johnson,Gwen Jang,Tasha L. Johnson,Erik Verschueren,Doug Sanders,Nevan J. Krogan,Megan L. Shaw,Renate König,Renate König,Silke Stertz,Adolfo García-Sastre,Sumit K. Chanda +38 more
TL;DR: A meta-analysis of data from eight published RNAi screens and integrated with three protein interaction datasets revealed a functionally validated biochemical landscape of the influenza-host interface, which illuminates a viral-host network of high-confidence human proteins that are essential for influenza A virus replication.
Journal ArticleDOI
Global landscape of HIV-human protein complexes
Stefanie Jäger,Peter Cimermancic,Peter Cimermancic,Natali Gulbahce,Natali Gulbahce,Jeffrey R. Johnson,Jeffrey R. Johnson,Jeffrey R. Johnson,Kathryn E. McGovern,Kathryn E. McGovern,Starlynn Clarke,Michael Shales,Michael Shales,Gaelle Mercenne,Lars Pache,Kathy H. Li,Kathy H. Li,Hilda Hernandez,Hilda Hernandez,Gwendolyn M. Jang,Gwendolyn M. Jang,Shoshannah L. Roth,Eyal Akiva,Eyal Akiva,John M. Marlett,Melanie L. Stephens,Iván D'Orso,Iván D'Orso,Jason D Fernandes,Marie E. Fahey,Marie E. Fahey,Cathal Mahon,Cathal Mahon,Anthony J. O’Donoghue,Aleksandar Todorovic,John H. Morris,David Maltby,Tom Alber,Gerard Cagney,Frederic D. Bushman,John A. T. Young,Sumit K. Chanda,Wesley I. Sundquist,Tanja Kortemme,Tanja Kortemme,Ryan D. Hernandez,Ryan D. Hernandez,Charles S. Craik,Charles S. Craik,Alma L. Burlingame,Alma L. Burlingame,Andrej Sali,Alan D. Frankel,Alan D. Frankel,Nevan J. Krogan +54 more
TL;DR: The use of affinity tagging and purification mass spectrometry is reported to determine systematically the physical interactions of all 18 HIV-1 proteins and polyproteins with host proteins in two different human cell lines (HEK293 and Jurkat).
Journal ArticleDOI
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Karine G. Le Roch,Jeffrey R. Johnson,Laurence Florens,Yingyao Zhou,Andrey Santrosyan,Munira Grainger,S. Frank Yan,Kim C. Williamson,Anthony A. Holder,Daniel J. Carucci,John R. Yates,Elizabeth A. Winzeler +11 more
TL;DR: Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.
Journal ArticleDOI
IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV
Kathryn M. Monroe,Zhiyuan Yang,Jeffrey R. Johnson,Xin Geng,Gilad Doitsh,Nevan J. Krogan,Nevan J. Krogan,Warner C. Greene +7 more
TL;DR: The intracellular sensor that triggers the death of human lymphoid CD4 T cells abortively infected with HIV is identified as interferon-γ–inducible protein 16 (IFI16), which senses viral DNA and activates pyroptosis, an inflammatory cell death pathway.
Journal ArticleDOI
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Sang-Won Min,Xu Chen,Tara E. Tracy,Yaqiao Li,Yungui Zhou,Chao Wang,Kotaro Shirakawa,S. Sakura Minami,Erwin Defensor,Sue-Ann Mok,Peter Dongmin Sohn,Birgit Schilling,Xin Cong,Lisa M. Ellerby,Bradford W. Gibson,Jeffrey R. Johnson,Nevan J. Krogan,Mehrdad Shamloo,Jason E. Gestwicki,Eliezer Masliah,Eric Verdin,Li Gan +21 more
TL;DR: Targeting tau acetylation could be a new therapeutic strategy against human tauopathies and a critical determinant in tau homeostasis and toxicity in mice.