Z
Zeqiu Han
Researcher at Georgetown University Medical Center
Publications - 20
Citations - 1332
Zeqiu Han is an academic researcher from Georgetown University Medical Center. The author has contributed to research in topics: Receptor & Translocator protein. The author has an hindex of 18, co-authored 20 publications receiving 1269 citations.
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Journal ArticleDOI
Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders.
TL;DR: Changes in peripheral-type benzodiazepine receptor and neurosteroid levels are part of the phenotype seen in neuropathology and neurological disorders and offer potential targets for new therapies.
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Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria
Thierry Hauet,Zhi-Xing Yao,Himangshu S. Bose,Christopher T. Wall,Zeqiu Han,Wenping Li,Dale B. Hales,Walter L. Miller,Martine Culty,Vassilios Papadopoulos +9 more
TL;DR: Reincorporation of in vitro transcribed/translated PBR, but not PBR missing the cholesterol-binding domain, into MA-10 mitochondria rescued the ability of the mitochondria to form steroids and the ability to respond to StAR and Tom/StAR proteins.
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Expression of Peripheral Benzodiazepine Receptor (PBR) in Human Tumors: Relationship to Breast, Colorectal, and Prostate Tumor Progression
TL;DR: It is proposed that PBR overexpression could serve as a novel prognostic indicator of an aggressive phenotype in breast, colorectal and prostate cancers, where elevated PBR expression is associated with tumor progression.
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Ginkgo biloba extract (Egb 761) inhibits β-amyloid production by lowering free cholesterol levels
TL;DR: It is indicated that free circulating and intracellular cholesterol levels affect the processing of beta-amyloid precursor protein and amyloidogenesis, and the first demonstration that EGb 761 can influence these mechanisms is provided.
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Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways.
TL;DR: It is suggested that in fibroblasts and fibrosarcoma cells PBR drug ligands inhibit cell proliferation in a PBR-independent manner, and this results are in contrast to data reported on cells of epithelial origin, suggesting that the origin of the cells is crucial in defining the role of PBR in their proliferation.