Z
Zequan Yang
Researcher at University of Virginia
Publications - 77
Citations - 3875
Zequan Yang is an academic researcher from University of Virginia. The author has contributed to research in topics: Myocardial infarction & Reperfusion injury. The author has an hindex of 30, co-authored 72 publications receiving 3536 citations. Previous affiliations of Zequan Yang include University of Virginia Health System.
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Journal ArticleDOI
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.
Ali Hafezi-Moghadam,Tommaso Simoncini,Zequan Yang,Florian P. Limbourg,Jean-Christophe Plumier,Michela C. Rebsamen,Chung-Ming Hsieh,Dao-Shan Chui,Kennard L. Thomas,Alyson Prorock,Victor E. Laubach,Michael A. Moskowitz,Brent A. French,Klaus Ley,James K. Liao +14 more
TL;DR: It is shown that high-dose corticosteroids exert cardiovascular protection through a novel mechanism involving the rapid, non-transcriptional activation of endothelial nitric oxide synthase (eNOS) in wild-type mice.
Journal ArticleDOI
Smooth muscle phenotypic modulation is an early event in aortic aneurysms.
Gorav Ailawadi,Christopher W. Moehle,Hong Pei,Sandra P Walton,Zequan Yang,Irving L. Kron,Christine L. Lau,Gary K. Owens +7 more
TL;DR: Aneurysms demonstrate smoother muscle cell phenotypic modulation characterized by downregulation of smooth muscle cell marker genes and upregulation of matrix metalloproteinases before aneurysm formation.
Journal ArticleDOI
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Zequan Yang,Yuan-Ji Day,Marie-Claire Toufektsian,Yaqin Xu,Susan I. Ramos,Melissa A. Marshall,Brent A. French,Joel Linden +7 more
TL;DR: It is shown that CD4+ but not CD8+ T lymphocytes contribute to myocardial ischemia/reperfusion injury and is strongly suggested that the infarct-sparing effect of A2AR activation is primarily due to inhibition of CD4-cell accumulation and activation in the reperfused heart.
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Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution.
TL;DR: The intensity of cardiomyocyte eGFP fluorescence measured on a cell-by-cell basis revealed that AAV-mediated gene expression in the heart can be modeled as a Poisson distribution, requiring an average of nearly two vector genomes per cell to attain an 85% transduction efficiency.
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Simultaneous Evaluation of Infarct Size and Cardiac Function in Intact Mice by Contrast-Enhanced Cardiac Magnetic Resonance Imaging Reveals Contractile Dysfunction in Noninfarcted Regions Early After Myocardial Infarction
TL;DR: MRI can accurately assess both infarct size and cardiac function in intact mice early after large, reperfused MI, revealing the existence of contractile dysfunction in noninfarcted regions of the heart.