Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H2 O2 /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. The polydopamine endowed antioxidant activity, tissue adhesiveness and hemostatic ability, self-healing ability, conductivity, and NIR irradiation enhanced in vivo antibacterial behavior of the hydrogels are investigated. Moreover, drug release and zone of inhibition tests confirm sustained drug release capacity of the hydrogels. Furthermore, the hydrogel dressings significantly enhance vascularization by upregulating growth factor expression of CD31 and improve the granulation tissue thickness and collagen deposition, all of which promote wound closure and contribute to a better therapeutic effect than the commercial Tegaderm films group in a mouse full-thickness wounds model. In summary, these adhesive hemostatic antioxidative conductive hydrogels with sustained drug release property to promote complete skin regeneration are an excellent wound dressing for full-thickness skin repair.

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing

Developing injectable antibacterial and conductive shape memory hemostatic with high blood absorption and fast recovery for irregularly shaped and noncompressible hemorrhage remains a challenge. Here we report injectable antibacterial conductive cryogels based on carbon nanotube (CNT) and glycidyl methacrylate functionalized quaternized chitosan for lethal noncompressible hemorrhage hemostasis and wound healing. These cryogels present robust mechanical strength, rapid blood-triggered shape recovery and absorption speed, and high blood uptake capacity. Moreover, cryogels show better blood-clotting ability, higher blood cell and platelet adhesion and activation than gelatin sponge and gauze. Cryogel with 4 mg/mL CNT (QCSG/CNT4) shows better hemostatic capability than gauze and gelatin hemostatic sponge in mouse-liver injury model and mouse-tail amputation model, and better wound healing performance than Tegaderm™ film. Importantly, QCSG/CNT4 presents excellent hemostatic performance in rabbit liver defect lethal noncompressible hemorrhage model and even better hemostatic ability than Combat Gauze in standardized circular liver bleeding model.

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Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing.

Hydrogels, due to their excellent biochemical and mechnical property, have shown attractive advantages in the field of wound dressings. However, a comprehensive review of the functional hydrogel as a wound dressing is still lacking. This work first summarizes the skin wound healing process and relates evaluation parameters and then reviews the advanced functions of hydrogel dressings such as antimicrobial property, adhesion and hemostasis, anti-inflammatory and anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, and the recently emerged wound monitoring feature, and the strategies adopted to achieve these functions are all classified and discussed. Furthermore, applications of hydrogel wound dressing for the treatment of different types of wounds such as incisional wound and the excisional wound are summarized. Chronic wounds are also mentioned, and the focus of attention on infected wounds, burn wounds, and diabetic wounds is discussed. Finally, the future directions of hydrogel wound dressings for wound healing are further proposed.

Functional Hydrogels as Wound Dressing to Enhance Wound Healing.

Self-healing hydrogels with multifunctionality as a type of fascinating material show potential application in various fields, such as biomedicine, tissue engineering, and wearable electronic devices. However, to combine the properties of autonomous self-healing property, high conductivity, excellent mechanical properties, and stimuli-responsive properties for hydrogel is still a great challenge. Herein, we present self-healing conductive hydrogels based on β-cyclodextrin (β-CD), N-isopropylacrylamide (NIPAM), multiwalled carbon nanotubes (CNT) and nanostructured polypyrrole (PPY). Among them, β-CD served as the host molecule, and NIPAM served as the guest molecule, CNT as the physical cross-linker and conducting substrate, and PPY as the highly conductive component, respectively. The obtained hydrogels exhibit high conductivity, self-healing property, flexible and elastic mechanical property and rapid stimuli-responsive property both to temperature and near-infrared (NIR)-light together. The excellent ch...

Multifunctional Stimuli-Responsive Hydrogels with Self-Healing, High Conductivity, and Rapid Recovery through Host–Guest Interactions

Self-healing, adhesive conductive hydrogels are of great significance in wearable electronic devices, flexible printable electronics, and tissue engineering scaffolds. However, designing self-healing hydrogels with multifunctional properties such as high conductivity, excellent mechanical property, and high sensitivity remains a challenge. In this work, the conductive self-healing nanocomposite hydrogels based on nanoclay (laponite), multiwalled carbon nanotubes (CNTs), and N-isopropyl acrylamide are presented. The presented nanocomposite hydrogels displayed good electrical conductivity, rapid self-healing and adhesive properties, flexible and stretchable mechanical properties, and high sensitivity to near-infrared light and temperature. These excellent properties of the hydrogels are demonstrated by the three-dimensional (3D) bulky pressure-dependent device, human activity monitoring device, and 3D printed gridding scaffolds. Good cytocompatibility of the conductive hydrogels was also evaluated with L929...

Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-Healing, Adhesiveness, and 3D Printability for Human Motion Sensing.

Conductive hydrogels have generated great interest in biomedical and electrical fields. However, conventional conductive hydrogels usually lack self-healing properties, which might be unfavorable for their application. Conductive self-healing hydrogels with excellent performance for applications in the biomedical and electrical fields are growing in number. In this review paper, the progress related to conductive self-healing hydrogels is summarized. The self-healing mechanism is classified to demonstrate the design and synthesis of conductive self-healing hydrogels and their applications in tissue engineering, wound healing, electronic skin, sensors and self-repaired circuits are presented and discussed. The future development of conductive self-healing hydrogels and problems that need to be solved are also described.

Self-healing conductive hydrogels: preparation, properties and applications

Stimuli-responsive conductive hydrogels have emerged as a new rising concept in the hydrogel research field due to their combined advantages of stimuli-responsivity and conductivity from conductive polymers (such as polyaniline, polypyrrole, and polythiophene), carbon nanomaterials (such as carbon nanotubes, graphene and graphene oxide), metals (such as Au and Ag), and conductive ionic compounds (such as Fe3+ and Al3+). To summarize the recent progress relating to stimuli-responsive conductive hydrogels, this review article discusses research into the preparation, performance, and applications of stimuli-responsive conductive hydrogels published in recent decades. The types of stimuli to which these hydrogels can respond, including temperature, pH, near-infrared (NIR) light, magnetic fields, electrical fields, and multiple stimuli, are classified and discussed. Applications of stimuli-responsive conductive hydrogels in sensors for human motion/health monitoring, electronic skin, on–off switchable electronic devices, actuators, controlled drug release, wound healing, photothermal therapy, tissue engineering, and cell delivery are demonstrated. Moreover, issues still needing to be solved and future directions for the development of new types of stimuli-responsive conductive hydrogels are also proposed in this review.

Zexing Deng

Papers

Multifunctional Stimuli-Responsive Hydrogels with Self-Healing, High Conductivity, and Rapid Recovery through Host–Guest Interactions

Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-Healing, Adhesiveness, and 3D Printability for Human Motion Sensing.

Self-healing conductive hydrogels: preparation, properties and applications

Stimuli-responsive conductive hydrogels: design, properties, and applications

Stretchable degradable and electroactive shape memory copolymers with tunable recovery temperature enhance myogenic differentiation.