Zhan-Cheng Zeng

TL;DR: This work is the first to reveal a circRNA that specifically influences FLT3-ITD AML and regulatesFLT3 kinase levels through translational regulation, suggesting that circMYBL2 may be a potential therapeutic target for F LT 3-ITd AML.

TL;DR: In this article, the authors summarize the function of these m6A methyltransferases or complexes in regulating the key genes and pathways of cancer biology and highlight the progress in the use of m6As in mediating therapy resistance, including chemotherapy, targeted therapy, immunotherapy and radiotherapy.

TL;DR: It is shown that circAF4 plays an oncogenic role in MLL-AF4 leukemia and promotes leukemogenesis in vitro and in vivo, and a number of circRNAs could originate from these partners, suggesting the potential roles of fusion gene partner-originating circ RNAs in leukemia with chromosomal translocations.

TL;DR: It is discovered that a long noncoding RNA (lncRNA) LAMP5-AS1 can promote higher degrees of H3K79 methylation, followed by upregulated expression of the self-renewal genes in the HOXA cluster, which are responsible for leukemia stemness in context of MLL rearrangements.

TL;DR: This study demonstrates that LAMP5 serves as a “bodyguard” for MLL fusions to evade degradation and is the first to link H3K79 methylation to autophagy regulation, highlighting the potential of LAMP 5 as a therapeutic target for Mll leukemia.