Zhan Fan

TL;DR: Monitoring the motility of MMs in deeper tissue around inflammatory foci with the development of type 1 diabetic mice through a switchable footpad skin optical clearing window demonstrated that progressive T1D led to the gradually potentiated MM recruitment and increased expression of monocyte chemoattractant protein‐1 during DTH, but MM migration displacement, motion velocity and motility coefficient were significantly attenuated.

TL;DR: It was found that monocytes formed clusters around hair follicles in the contact hypersensitivity model, which provided a new perspective on effector T cell-regulated monocyte behavior, which amplifies the inflammatory reaction in acquired cutaneous immunity.

TL;DR: Mammalian target of rapamycin (mTOR), a serine/threonine kinase orchestrating cellular metabolism, is a crucial immune system regulator and this study provides an intuitive approach for the early prediction of DC function through morphological quantification of form factor and area.

TL;DR: The investigation of the sinusoidal network and DC/macrophage arrangements through the liver-CUBIC approach and whole-mount imaging provide a powerful platform for understanding hepatic circulatory properties and immune surveillance in the liver.

TL;DR: In this article, an immunomodulatory approach based on lipid nanoparticles carrying α-helical configurational melittin (α•melittin•NP) is developed to overcome T cell-mediated inflammatory reactions in an oxazolone (OXA)-induced contact hypersensitivity mouse model and OXA-induced AD-like mouse model.