Zhan Yang

TL;DR: These findings have linked p53/RBM25-mediated circAMOTL1L-miR-193a-5p-Pcdha8 regulatory axis to EMT in metastatic progression of PCa, and Targeting this newly identified regulatory axis provides a potential therapeutic strategy for aggressive PCa.

TL;DR: In vivo studies demonstrated that the localization of the interaction of circACTA2 with miR-548f-5p is significantly decreased in human intimal hyperplastic arteries compared with normal arteries, implicating that dysregulation of circ ACTA2 and miR/miR/548f/5p expression is involved in intimalhyperplasia.

TL;DR: Limiting the expression of Bach2, a repressor of the HO-1 gene, by directly targeting the Bach2 mRNA 3′-UTR may be a novel therapeutic approach for castration-resistant PC through silencing or blockade of the miR-193a-5p-Bach2-HO-1 pathway.

TL;DR: A novel mechanism whereby KLF4 mediates the link between TGF‐β1‐induced gene transcription activation and H3 acetylation during VSMC differentiation is revealed.

TL;DR: In this paper, the authors showed that miR-155 directly repressed mammalian sterile 20-like kinase 2 (MST2) and activated the extracellular signal-regulated kinase (ERK) pathway by promoting an interaction between RAF proto-oncogene serine/threonine-protein kinases (Raf-1) and mitogen-activated protein kinase kinase(MEK) and stimulating inflammatory and oxidative stress responses; together, these effects lead to VSMC proliferation and vascular remodeling.