Kai-Long Liu

TL;DR: These findings have linked p53/RBM25-mediated circAMOTL1L-miR-193a-5p-Pcdha8 regulatory axis to EMT in metastatic progression of PCa, and Targeting this newly identified regulatory axis provides a potential therapeutic strategy for aggressive PCa.

TL;DR: Limiting the expression of Bach2, a repressor of the HO-1 gene, by directly targeting the Bach2 mRNA 3′-UTR may be a novel therapeutic approach for castration-resistant PC through silencing or blockade of the miR-193a-5p-Bach2-HO-1 pathway.

TL;DR: In this paper, a CRISPR-Cas9-based complex was used to activate endogenous CDK13 and circCDK13 expression in human PCa tissues and different cell lines were determined by quantitative real-time PCR and Western blot analysis.

TL;DR: A novel regulatory mechanism underlying the miR-20b-5p/TGFBR2/E2F1 axis is involved in TGF-β1-induced EMT of PCa cells, and miR+5p may be a potential therapeutic target for PCa.

TL;DR: Evidence is provided that the regulatory feedback loop among RBM5, miR‐432‐5p, and Wnt–²‐catenin is responsible for the progress of bladder cancer cells, and this study found that R BM5 expression was significantly down‐regulated in BUC tissues when compared with the adjacent nontumor tissues.