Z
Zhen Gao
Researcher at The Chinese University of Hong Kong
Publications - 3
Citations - 151
Zhen Gao is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Oxidative stress & Endothelium. The author has an hindex of 3, co-authored 3 publications receiving 123 citations.
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Journal ArticleDOI
Inhibition of miR-200c Restores Endothelial Function in Diabetic Mice Through Suppression of COX-2
Huina Zhang,Jian Liu,Dan Qu,Li Wang,Jiang-Yun Luo,Chi Wai Lau,Pingsheng Liu,Zhen Gao,George L. Tipoe,Hung Kay Lee,Chi-Fai Ng,Ronald C.W. Ma,Xiaoqiang Yao,Yu Huang +13 more
TL;DR: This study demonstrates for the first time to the knowledge that miR-200c is a new mediator of diabetic endothelial dysfunction and inhibition of miR -200c rescues EDRs in diabetic mice, and suggests the potential usefulness ofmiR- 200c as the target for drug intervention against diabetic vascular complications.
Journal ArticleDOI
Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats
Youhua Wang,Jinghui Dong,Ping Liu,Chi Wai Lau,Zhen Gao,Duan Zhou,Jingyi Tang,Chi-Fai Ng,Yu Huang +8 more
TL;DR: This study investigated the mechanisms underlying the vascular benefits of ginsenoside Rb3 (Rb3) in hypertension by studying its application in cardiovascular conditions in Oriental countries.
Journal ArticleDOI
Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries
Zhen Gao,Huina Zhang,Jian Liu,Chi Wai Lau,Pingsheng Liu,Zhen-Yu Chen,Hung Kay Lee,George L. Tipoe,Hing Man Ho,Xiaoqiang Yao,Yu Huang +10 more
TL;DR: Novel evidence is provided that palmitate up-regulates COX-2 through NF-κB-dependent mechanism and resultant COx-2-associated oxidative stress impairs endothelium-dependent relaxations in mouse aortas.