J
Jian Liu
Researcher at The Chinese University of Hong Kong
Publications - 34
Citations - 1783
Jian Liu is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Endothelium & Endothelial dysfunction. The author has an hindex of 23, co-authored 31 publications receiving 1393 citations. Previous affiliations of Jian Liu include Houston Methodist Hospital.
Papers
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Journal ArticleDOI
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
Li Wang,Jiang-Yun Luo,Bochuan Li,Xiao Yu Tian,Li-Jing Chen,Yuhong Huang,Jian Liu,Dan Deng,Chi Wai Lau,Song Wan,Ding Ai,Kinglun Kingston Mak,Ka Kui Tong,Kin Ming Kwan,Nanping Wang,Jeng-Jiann Chiu,Yi Zhu,Yu Huang +17 more
TL;DR: The results indicate that integrin–Gα13–RhoA–YAP pathway holds promise as a novel drug target against atherosclerosis.
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Dipeptidyl Peptidase 4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension Through a Glucagon–Like Peptide 1–Dependent Mechanism
Limei Liu,Jian Liu,Wing Tak Wong,Xiao Yu Tian,Chi Wai Lau,Yi-Xiang J. Wang,Gang Xu,Yunfei Pu,Zhiming Zhu,Aimin Xu,Karen S.L. Lam,Karen S.L. Lam,Zhen-Yu Chen,Chi-Fai Ng,Xiaoqiang Yao,Yu Huang +15 more
TL;DR: It is elucidate that upregulation of GLP-1 and related agents improve endothelial function in hypertension by restoring NO bioavailability, suggesting that GLp-1 signaling could be a therapeutic target in hypertension-related vascular events.
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IL-6 in diabetes and cardiovascular complications
TL;DR: The present review discusses its roles in diabetes and associated cardiovascular complications, with emphasis on the different outcomes mediated by the two modes of IL‐6 signalling and the value of developing therapeutic strategies to specifically target the deleterious trans‐signalling ofIL‐6.
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Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes
Huina Zhang,Huina Zhang,Jian Liu,Dan Qu,Li Wang,Chi-Ming Wong,Chi Wai Lau,Yuhong Huang,Yifan Wang,Huihui Huang,Yin Xia,Li Xiang,Zongwei Cai,Pingsheng Liu,Yongxiang Wei,Xiaoqiang Yao,Ronald C.W. Ma,Yu Huang +17 more
TL;DR: It is demonstrated that SExos deliver arginase 1 protein to endothelial cells, representing a cellular mechanism during development of diabetic endothelial dysfunction, and the results expand the scope of blood-borne substances that monitor vascular homeostasis.
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Uncoupling Protein-2 Mediates DPP-4 Inhibitor-Induced Restoration of Endothelial Function in Hypertension Through Reducing Oxidative Stress
Limei Liu,Jian Liu,Xiao Yu Tian,Wing Tak Wong,Chi Wai Lau,Aimin Xu,Gang Xu,Chi-Fai Ng,Xiaoqiang Yao,Yuansheng Gao,Yu Huang +10 more
TL;DR: It is elucidate for the first time that UCP2 serves as an important signal molecule in endothelial protection conferred by GLP-1-related agents and could be a useful target in treating hypertension-related vascular events.