Z
Zhen Lin
Researcher at Fujian Medical University
Publications - 59
Citations - 2253
Zhen Lin is an academic researcher from Fujian Medical University. The author has contributed to research in topics: Osteoclast & Tendon. The author has an hindex of 25, co-authored 54 publications receiving 1902 citations. Previous affiliations of Zhen Lin include University of Illinois at Urbana–Champaign & École centrale de Lyon.
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Journal ArticleDOI
The chondrocyte: biology and clinical application.
TL;DR: The potential of chondrocyte implantation for facial reconstruction, the treatment of long segmental tracheal defects, and urinary incontinence and vesicoureteral reflux are being investigated.
Journal ArticleDOI
Gene Expression Profiles of Human Chondrocytes during Passaged Monolayer Cultivation
Zhen Lin,Jonathan B. Fitzgerald,Jiake Xu,Craig Willers,David Wood,Alan J. Grodzinsky,Ming H. Zheng +6 more
TL;DR: C cultured chondrocytes undergo dedifferentiation during monolayer culture, although the gene expression level of transcription factors necessary for chondrogenesis remains unchanged, which may prove important for the future development of more specific and efficacious cultivation techniques for human articular chondROcyte‐based therapies.
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V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption.
TL;DR: The structure and function of V-ATPase subunits are reviewed, emphasizing their exquisite roles in osteoclastic function and leading to the development of osteoclast-specific V- ATPase inhibitors that may serve as alternative therapies for the treatment of osteolytic diseases.
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Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.
Zanjing Zhai,Huiwu Li,Guangwang Liu,Xinhua Qu,Bo Tian,W Yan,Zhen Lin,Zhen Lin,Tingting Tang,An Qin,An Qin,Kerong Dai +11 more
TL;DR: Changes in osteoclastogenesis and LPS‐induced osteolysis in response to andrographolide (AP), a diterpenoid lactone isolated from the traditional Chinese and Indian medicinal plant Andrographis paniculata are examined.
Journal ArticleDOI
Programmable mechanical stimulation influences tendon homeostasis in a bioreactor system.
Tao Wang,Zhen Lin,Zhen Lin,Robert E. Day,Bruce S. Gardiner,Euphemie Landao-Bassonga,Jonas Rubenson,Thomas Brett Kirk,David Smith,David Lloyd,Gerard Hardisty,Allan Wang,Qiujian Zheng,Ming H. Zheng +13 more
TL;DR: The data indicated that an optimal PMS is required to maintain the tendon homeostasis and there is only a narrow range of tensile strain that can induce the anabolic action.