Zhen Qiu

TL;DR: Genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain revealed spatial architecture from dendritic to global systems levels and previously unknown anatomical features.

TL;DR: Although synapse density generally increased in early development and declined in old age, the details differed in different brain areas, and a continuum of changes alters synapse composition in all brain regions across the life span.

TL;DR: A novel feature-preserving non-local means filter that achieves higher peak signal-to-noise ratio in denoised images and has a greater capability in identifying weak particles when applied to synthetic data is presented.

TL;DR: It is shown, using molecular imaging, that the majority of tSNARE molecules are spatially separated from secretory vesicles, providing a new model for the molecular mechanism of regulated exocytosis and demonstrating the exquisite organization of the plasma membrane at the level of individual molecular machines.

TL;DR: A robust framework for particle detection in which image denoising in the grayscale image is not needed, so avoiding image oversmoothing and significant improvements in particle detection and tracking efficiency in fluorescence live-cell applications are proposed.