Z
Zhengbo Wang
Researcher at Kunming Institute of Zoology
Publications - 28
Citations - 516
Zhengbo Wang is an academic researcher from Kunming Institute of Zoology. The author has contributed to research in topics: Neural stem cell & Stem cell. The author has an hindex of 10, co-authored 26 publications receiving 351 citations. Previous affiliations of Zhengbo Wang include Kunming University of Science and Technology.
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Journal ArticleDOI
Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain.
Siling Liu,Siling Liu,Zhengbo Wang,Dong Chen,Bowen Zhang,Ren-Rong Tian,Jing Wu,Ying Zhang,Kaiyu Xu,Kaiyu Xu,Liu-Meng Yang,Chao Cheng,Jian Ma,Jian Ma,Longbao Lv,Longbao Lv,Yong-Tang Zheng,Yong-Tang Zheng,Xintian Hu,Xintian Hu,Xintian Hu,Yi Zhang,Xiangting Wang,Xiangting Wang,Jiali Li,Jiali Li +25 more
TL;DR: These findings offer a fresh insight into spatial-, age-, and sex-biased changes in lncRNA expression in macaque brain and suggest that the changes represent a previously unappreciated regulatory system that potentially contributes to brain development and aging.
Journal ArticleDOI
Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells.
Xiaping He,Zhenhui Li,Joshua D. Rizak,Shihao Wu,Shihao Wu,Zhengbo Wang,Rongqiao He,Min Su,Dongdong Qin,Jingkun Wang,Xintian Hu +10 more
TL;DR: Findings provide evidence that Res protects N2a cells from FA-induced damages and suggests that inhibition of GSK-3β and CaMKII and the activation of PP2A by Res protect against the hyperphosphorylation and/or mediates the deph phosphorylation of tau protein, respectively.
Journal ArticleDOI
Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain
Weili Yang,Guohao Wang,Chuan-En Wang,Xiangyu Guo,Peng Yin,Jinquan Gao,Zhuchi Tu,Zhengbo Wang,Jing Wu,Xintian Hu,Shihua Li,Xiao-Jiang Li +11 more
TL;DR: It is found that α-synuclein is increased in the older monkey brains, whereas Parkin and PINK1 are decreased or remain unchanged, and aging also increases the accumulation of A53T in neurites and its associated neuropathology.
Journal ArticleDOI
Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging.
Kaiyu Xu,Dong Chen,Zhengbo Wang,Jian Ma,Jian Zhou,Nan-Hui Chen,Longbao Lv,Longbao Lv,Yong-Tang Zheng,Yong-Tang Zheng,Xintian Hu,Xintian Hu,Yi Zhang,Jiali Li,Jiali Li +14 more
TL;DR: A comprehensive map of changes in circRNA expression in rhesus macaque brain in two age groups from adult (10 y) to aged (20’y) periods is explored to reveal insights into a potentially circRNA-mediated regulatory mechanism underlying the biology of brain aging.
Journal ArticleDOI
Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol
Meifeng Yang,Junye Miao,Joshua D. Rizak,Rongwei Zhai,Zhengbo Wang,Tanzeel Huma,Ting Li,Na Zheng,Shihao Wu,Yingwei Zheng,Xiaona Fan,Jianzhen Yang,Jianhong Wang,Shangchuan Yang,Yuanye Ma,Longbao Lü,Rongqiao He,Xintian Hu +17 more
TL;DR: The presence of amyloid plaque formations in the monkeys highlighted a marked difference in animal systems used in AD investigations, suggesting that the innate defenses in mice against methanol toxicity may have limited previous investigations into AD pathology.