Z
Zhengyu Fang
Researcher at Fudan University
Publications - 5
Citations - 100
Zhengyu Fang is an academic researcher from Fudan University. The author has contributed to research in topics: Integrin & Collagen receptor. The author has an hindex of 4, co-authored 5 publications receiving 96 citations.
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Journal ArticleDOI
Increase in β1‐6 GlcNAc branching caused by N‐acetylglucosaminyltransferase V directs integrin β1 stability in human hepatocellular carcinoma cell line SMMC‐7721
Liying Wang,Yulong Liang,Zengxia Li,Xiumei Cai,Wen Zhang,Guoqiang Wu,Jiawei Jin,Zhengyu Fang,Yong Yang,Xiliang Zha +9 more
TL;DR: The results suggest that the addition of β1‐6 GlcNAc branching caused more fully glycosylated mature form on integrin β1 and inhibited β1 protein degradation.
Journal ArticleDOI
Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin β1-actin complex in breast cancer cells.
Wantong Yao,Xianjun Yu,Zhengyu Fang,Peng Yin,Chao Zhao,Na Li,Liying Wang,Zengxia Li,Xiliang Zha +8 more
TL;DR: This study indicated a previously uncharacterized role of Pfn1 in mediating staurosporine‐inducing apoptosis in breast cancer cells via up‐regulating integrin α5β1, and suggested a new target for breast cancer therapy.
Journal ArticleDOI
Overexpression of integrin β1 inhibits proliferation of hepatocellular carcinoma cell SMMC‐7721 through preventing Skp2‐dependent degradation of p27 via PI3K pathway
Yi Fu,Zhengyu Fang,Yulong Liang,Xiaodong Zhu,Peterbram Prins,Zengxia Li,Liying Wang,Lidong Sun,Jiawei Jin,Yong Yang,Xiliang Zha +10 more
TL;DR: Results suggested that overexpression of integrin β1 inhibited cell proliferation by preventing the Skp2‐dependent degradation of p27Kip1 via PI3K pathway.
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Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin αVβ3
TL;DR: The results indicated that the integrin αVβ3 antibody (LM609) could block the Angptl3-induced protein kinase B phosphorylation and LY294002, a phosphatidylinositol-3 kinase inhibitor, could prevent the increase of permeability of GEnCs induced by AngPTl3.
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Integrin β1A Upregulates p27 Protein Amount at the Post-translational Level in Human Hepatocellular Carcinoma Cell Line SMMC-7721
TL;DR: Results indicated that integrin beta(1A) might upregulate the protein amount of p27 through repressing Skp2-dependent proteasome degradation and calpain-mediated proteolysis in SMMC-7721 cells.