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Yong Yang
Researcher at Fudan University
Publications - 16
Citations - 480
Yong Yang is an academic researcher from Fudan University. The author has contributed to research in topics: Cell growth & Collagen receptor. The author has an hindex of 14, co-authored 16 publications receiving 461 citations. Previous affiliations of Yong Yang include Fudan University Shanghai Medical College & Chinese Ministry of Education.
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Journal ArticleDOI
Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines is involved in inhibition of cell proliferation and migration.
Nan Wu,Wen Zhang,Yong Yang,Yulong Liang,Liying Wang,Jiawei Jin,Xiumei Cai,Xiliang Zha,Xiliang Zha,Xiliang Zha +9 more
TL;DR: It was found that the protein level of PFN1 was lower in hepatocarcinoma tissues compared to that in the adjacent tissues, and similar to ATRA, overexpression ofPFN1 led to inhibition of cell proliferation and migration.
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Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression.
TL;DR: PTEN could inhibit cell invasion even in the presence of the constitutively active EGFR; this inhibition depended on its protein phosphatase activity, partially by dephosphorylating FAK, but not on its lipid phosphat enzyme activity.
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N‐Glycosylation affects the adhesive function of E‐Cadherin through modifying the composition of adherens junctions (AJs) in human breast carcinoma cell line MDA‐MB‐435
Hongbo Zhao,Yulong Liang,Zhibin Xu,Zhibin Xu,Liying Wang,Liying Wang,Feng Zhou,Feng Zhou,Zengxia Li,Jiawei Jin,Yong Yang,Zhengyu Fang,Yali Hu,Lineng Zhang,Jianmin Su,Jianmin Su,Xiliang Zha,Xiliang Zha +17 more
TL;DR: It is demonstrated that N‐glycosylation may affect the adhesive function of E‐cadherin through modifying the composition of adherens junctions at AJs.
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Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD
Feng Zhou,Jianmin Su,Le Fu,Yong Yang,Lineng Zhang,Liying Wang,Hongbo Zhao,Dian-cai Zhang,Zengxia Li,Xiliang Zha +9 more
TL;DR: It is revealed that N-glycosylation at Asn-633 is essential for E-cadherin expression, folding and trafficking.
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Post‐transcriptional and post‐translational regulation of PTEN by transforming growth factor‐β1
Yong Yang,Feng Zhou,Zengyu Fang,Liying Wang,Zengxia Li,Lidong Sun,Can Wang,Wantong Yao,Xiumei Cai,Jiawei Jin,Xiliang Zha +10 more
TL;DR: TGF‐β1 down‐regulates PTEN mRNA and protein expression in a dose‐ and time‐dependent manner in hepatocarcinoma cell line SMMC‐7721 and it is found that PTEN transcription is not affected by TGF‐ β1.