L
Lidong Sun
Researcher at Huazhong University of Science and Technology
Publications - 25
Citations - 757
Lidong Sun is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Histone & Biology. The author has an hindex of 14, co-authored 21 publications receiving 650 citations. Previous affiliations of Lidong Sun include Moffitt Cancer Center & Fudan University.
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Journal ArticleDOI
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Lidong Sun,Kenji Kokura,John R. Horton,Mikiko Fukuda,Alexsandra Espejo,Victoria Izumi,John M. Koomen,Mark T. Bedford,Xing Zhang,Yoichi Shinkai,Jia Fang,Xiaodong Cheng +11 more
TL;DR: Findings provide a molecular explanation, at least in part, for the co-occurrence of DNA methylation and H3K9 methylation in chromatin.
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Methyl‐H3K9‐binding protein MPP8 mediates E‐cadherin gene silencing and promotes tumour cell motility and invasion
TL;DR: A model by which MPP8 recognizes methyl‐H3K9 marks and directs DNA methylation to repress tumour suppressor gene expression and, in turn, has an important function in epithelial‐to‐mesenchymal transition and metastasis is suggested.
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Epigenetic regulation of epithelial-mesenchymal transition.
Lidong Sun,Jia Fang +1 more
TL;DR: A thorough understanding of the functions of epigenetic modifications in EMT will not only provide new insights into the knowledge of cancer progression and metastasis, but also facilitate the development of diagnostic and therapeutic strategies for human malignancy.
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Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation.
Lidong Sun,Hongbo Zhao,Zhibin Xu,Qinglan Liu,Yulong Liang,Liying Wang,Xiumei Cai,Lineng Zhang,Libing Hu,Guomin Wang,Xiliang Zha +10 more
TL;DR: It is suggested that PKB enhanced DNMT1 stability and maintained DNA methylation and chromatin structure, which might contribute to cancer cell growth.
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MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial–mesenchymal transition
TL;DR: It is shown that MPP8 cooperates with the class III HDAC SIRT1 in this process through their physical interaction and reciprocally promote each other's function and coordinate epithelial gene silencing and EMT.