Z
Zhenshan Liu
Researcher at Tongji University
Publications - 6
Citations - 951
Zhenshan Liu is an academic researcher from Tongji University. The author has contributed to research in topics: Induced pluripotent stem cell & Transcriptome. The author has an hindex of 5, co-authored 6 publications receiving 822 citations. Previous affiliations of Zhenshan Liu include University of California, Los Angeles.
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Journal ArticleDOI
Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing
Zhigang Xue,Kevin Huang,Chaochao Cai,Lingbo Cai,Chunyan Jiang,Yun Feng,Zhenshan Liu,Qiao Zeng,Liming Cheng,Yi E. Sun,Jiayin Liu,Steve Horvath,Guoping Fan +12 more
TL;DR: A comprehensive analysis of transcriptome dynamics from oocyte to morula in both human and mouse embryos, using single-cell RNA sequencing finds that each developmental stage can be delineated concisely by a small number of functional modules of co-expressed genes.
Journal ArticleDOI
A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells
Kevin Huang,Yin Shen,Zhigang Xue,Zhigang Xue,Marina Bibikova,Craig April,Zhenshan Liu,Zhenshan Liu,Linzhao Cheng,Andras Nagy,Matteo Pellegrini,Jian-Bing Fan,Guoping Fan +12 more
TL;DR: Overall, this study concludes that DNMT3B is involved in a wave of de novo methylation during reprogramming, a portion of which contributes to the unique hiPSC methylation signature.
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Identification of miRNA Signatures during the Differentiation of hESCs into Retinal Pigment Epithelial Cells
Ganlu Hu,Kevin Huang,Juehua Yu,Sailesh Gopalakrishna-Pillai,Jun Kong,He Xu,Zhenshan Liu,Kunshan Zhang,Jun Xu,Yuping Luo,Siguang Li,Yi E. Sun,Linda E. Iverson,Zhigang Xue,Guoping Fan +14 more
TL;DR: The overall miRNA landscape in RPE is distinct from ESCs and other differentiated somatic tissues, and it is suggested that RPE-specific miRNAs likely contribute to the functional maturation of RPE in vitro, similar to the regulation of R PE-specific mRNA expression.
Journal ArticleDOI
Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells
Kevin Huang,Zhourui Wu,Zhenshan Liu,Ganlu Hu,Juehua Yu,Kai H. Chang,Kee-Pyo Kim,Thuc Le,Kym F. Faull,Nagesh Rao,Andrew R. Gennery,Zhigang Xue,Cun-Yu Wang,Matteo Pellegrini,Guoping Fan +14 more
TL;DR: Results show specific methylome and transcriptome defects in both ICF1-iPSCs and differentiated somatic cell lineages, providing a valuable stem cell system for further in vitro study of the molecular pathogenesis of ICF 1 syndrome.
Journal ArticleDOI
Integrated Analysis of DNA Methylation and RNA Transcriptome during In Vitro Differentiation of Human Pluripotent Stem Cells into Retinal Pigment Epithelial Cells
Zhenshan Liu,Rongfeng Jiang,Songtao Yuan,Na Wang,Yun Feng,Ganlu Hu,Xianmin Zhu,Kevin Huang,Jieliang Ma,Guo-Tong Xu,Qinghuai Liu,Zhigang Xue,Guoping Fan +12 more
TL;DR: The results demonstrate that DNA methylation may serve as biomarkers to characterize the cell differentiation process during the conversion of human pluripotent stem cells into functional RPE cells.