Z
Zhenshan Zhang
Researcher at Chinese Academy of Sciences
Publications - 8
Citations - 178
Zhenshan Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Quantitative structure–activity relationship & Binding site. The author has an hindex of 7, co-authored 8 publications receiving 166 citations.
Papers
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Journal ArticleDOI
Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).
TL;DR: MCSS and LeapFrog, two de novo drug design programs, were used for the novel indole-based PPARgamma ligands' study, and two molecules possessed potent PPargamma protein binding activity close to rosiglitazone in vitro.
Journal ArticleDOI
Towards discovering dual functional inhibitors against both wild type and K103N mutant HIV-1 reverse transcriptases: molecular docking and QSAR studies on 4,1-benzoxazepinone analogues.
Zhenshan Zhang,Mingyue Zheng,Li Du,Jianhua Shen,Xiaomin Luo,Weiliang Zhu,Hualiang Jiang,Hualiang Jiang +7 more
TL;DR: To find useful information for discovering dual functional inhibitors against both wild type (WT) and K103N mutant reverse transcriptases (RTs) of HIV-1, molecular docking and 3D-QSAR approaches were applied to a set of 4,1-benzoxazepinone analogues of efavirenz, finding two potent inhibitors from the compound database SPECS.
Patent
Method for predicting compound carcinogenic toxicity based on complex sampling and improved decision forest algorithm
Hualiang Jiang,Xiaomin Luo,Zhenshan Zhang,Weiliang Zhu,Mingyue Zheng,Jianhua Shen,Kaixian Chen,Chunxia Xue +7 more
TL;DR: In this paper, the authors proposed a method for predicting compound carcinogenic toxicity based on complex sampling and an improved decision forest algorithm, which has favorable application prospect in high throughput virtual selection and calculating the carcinogen toxicity evaluation.