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Weiliang Zhu
Researcher at Chinese Academy of Sciences
Publications - 383
Citations - 11774
Weiliang Zhu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Hydrogen bond. The author has an hindex of 46, co-authored 365 publications receiving 9872 citations. Previous affiliations of Weiliang Zhu include Weizmann Institute of Science & Nanchang University.
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Predicting protein-protein interactions based only on sequences information.
Juwen Shen,Jian Zhang,Xiaomin Luo,Weiliang Zhu,Kunqian Yu,Kaixian Chen,Yixue Li,Hualiang Jiang +7 more
TL;DR: Different types of PPI networks have been effectively mapped with the proposed method, suggesting that, even with only sequence information, this method could be applied to the exploration of networks for any newly discovered protein with unknown biological relativity.
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Halogen bonding--a novel interaction for rational drug design?
Yunxiang Lu,Ting Shi,Yong Wang,Huaiyu Yang,Xiuhua Yan,Xiaoming Luo,Hualiang Jiang,Weiliang Zhu +7 more
TL;DR: A detailed analysis of the interactions reveals that halogen bonding interactions are responsible for the different conformation of the molecules in the active site and single-point energy calculations unveil that the interaction becomes comparable in magnitude to classical hydrogen bonding.
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TarFisDock: a web server for identifying drug targets with docking approach
Honglin Li,Zhenting Gao,Ling Kang,Hailei Zhang,Kun Yang,Kunqian Yu,Xiaomin Luo,Weiliang Zhu,Kaixian Chen,Jianhua Shen,Xicheng Wang,Hualiang Jiang +11 more
TL;DR: TarFisDock may be a useful tool for target identification, mechanism study of old drugs and probes discovered from natural products, and a reverse ligand–protein docking program for seeking potential protein targets by screening an appropriate protein database.
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Nonbonding interactions of organic halogens in biological systems: implications for drug discovery and biomolecular design
TL;DR: This Perspective focuses on nonbonding interactions of halogens from both crystallographic data and theoretical viewpoints and finds that organic halogen atoms are favorably involved in a wide variety of noncovalent protein-ligand interactions that show remarkable differences in terms of the geometrical and energetic features.
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Halogen bond: its role beyond drug-target binding affinity for drug discovery and development.
TL;DR: It is suggested that albeit halogenation is a valuable approach for improving ligand bioactivity, more attention should be paid in the future to the application of the halogen bond for ligand ADME/T property optimization.