Electrospinning for Tissue Engineering Applications

Bone tissue engineering (BTE) is a rapidly growing field aiming to create a biofunctional tissue that can integrate and degrade in vivo to treat diseased or damaged tissue. It has become evident that scaffold fabrication techniques are very important in dictating the final structural, mechanical properties, and biological response of the implanted biomaterials. A comprehensive review of the current accomplishments on scaffold fabrication techniques, their structure, and function properties for BTE is provided herein. Different types of biomaterials ranging from inorganic biomaterials to natural and synthetic polymers and related composites for scaffold processing are presented. Emergent scaffolding techniques such as electrospinning, freeze-drying, bioprinting, and decellularization are also discussed. Strategies to improve vascularization potential and immunomodulation, which is considered a grand challenge in BTE scaffolding, are also presented.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202010609

Scaffold fabrication technologies and structure/function properties in bone tissue engineering

Bacterial cellulose (BC), with non-toxicity, high purity, and biocompatibility, has been considered as a versatile candidate for various biomedical applications. Recently, the fabrication of BC-bas...

Bacterial Cellulose-Based Composite Scaffolds for Biomedical Applications: A Review

This review provides a detailed overview of the rapidly advancing field of biofabrication, particularly with regards to the use of photo-cross-linking (i.e., light-based) techniques. The major emphasis of this review is on the fundamentals of photo-cross-linking and key criteria identified for the successful design and implementation of photo-cross-linked bioinks and bioresins in extrusion-based and lithography-based bioprinting. The general mechanisms associated with photo-cross-linking (e.g., free-radical chain polymerization, thiol-ene, photomediated redox) of natural and synthetic materials are described to inform bioink and bioresin design, which includes the selection of polymers, functional group modifications, photoinitiators, and light sources that enable facile and cytocompatible photo-cross-linking. Depending on material selection and the bioprinting technique of interest, we describe the specific bioink or bioresin properties and criteria that must be achieved to ensure optimal printability and utility. Finally, examples of current state-of-the-art applications of light-based bioprinting for in vitro tissue models, tissue engineering, and regenerative medicine are provided to further motivate future opportunities within the bioprinting landscape that are facilitated with light.

Fundamentals and Applications of Photo-Cross-Linking in Bioprinting.

Bone tissue is the structural component of the body, which allows locomotion, protects vital internal organs, and provides the maintenance of mineral homeostasis. Several bone-related pathologies generate critical-size bone defects that our organism is not able to heal spontaneously and require a therapeutic action. Conventional therapies span from pharmacological to interventional methodologies, all of them characterized by several drawbacks. To circumvent these effects, tissue engineering and regenerative medicine are innovative and promising approaches that exploit the capability of bone progenitors, especially mesenchymal stem cells, to differentiate into functional bone cells. So far, several materials have been tested in order to guarantee the specific requirements for bone tissue regeneration, ranging from the material biocompatibility to the ideal 3D bone-like architectural structure. In this review, we analyse the state-of-the-art of the most widespread polymeric scaffold materials and their application in in vitro and in vivo models, in order to evaluate their usability in the field of bone tissue engineering. Here, we will present several adopted strategies in scaffold production, from the different combination of materials, to chemical factor inclusion, embedding of cells, and manufacturing technology improvement.

https://www.mdpi.com/2073-4360/12/4/905/pdf

Natural and Synthetic Polymers for Bone Scaffolds Optimization.

Bone tissue engineering has been continuously developing since the concept of “tissue engineering” has been proposed. Biomaterials that are used as the basic material for the fabrication of scaffolds play a vital role in bone tissue engineering. This paper first introduces a strategy for literature search. Then, it describes the structure, mechanical properties and materials of natural bone and the strategies of bone tissue engineering. Particularly, it focuses on the current knowledge about biomaterials used in the fabrication of bone tissue engineering scaffolds, which includes the history, types, properties and applications of biomaterials. The effects of additives such as signaling molecules, stem cells, and functional materials on the performance of the scaffolds are also discussed.

/pdf/biomaterials-for-bone-tissue-engineering-scaffolds-a-review-4epanp5xdo.pdf

Biomaterials for bone tissue engineering scaffolds: a review

/pdf/fractal-design-boosts-extrusion-based-3d-printing-of-bone-3y2xiq7uvn.pdf

Fractal Design Boosts Extrusion-Based 3D Printing of Bone-Mimicking Radial-Gradient Scaffolds

Review of methods for enhancing interlaminar mechanical properties of fiber-reinforced thermoplastic composites: Interfacial modification, nano-filling and forming technology

Zhenyu Han

Papers

Biomaterials for bone tissue engineering scaffolds: a review

Fractal Design Boosts Extrusion-Based 3D Printing of Bone-Mimicking Radial-Gradient Scaffolds

Review of methods for enhancing interlaminar mechanical properties of fiber-reinforced thermoplastic composites: Interfacial modification, nano-filling and forming technology

Intelligent tool wear prediction based on Informer encoder and stacked bidirectional gated recurrent unit

The interlaminar performance of carbon fiber reinforced polyetheretherketone composites reinforced by doped buckypaper