Zhi-Xin Liao

TL;DR: Three new Pt(IV) complexes comprising a combretastatin A-4 analogue could significantly improve the antiproliferative activity and overcome the drug resistance of cisplatin in vitro and have the ability to effectively inhibit the tumor growth in the HepG-2 xenograft model.

TL;DR: The results demonstrated that these compounds may induce apoptosis through a mitochondrion-dependent pathway and involved G1 phase arrest by increasing the production of intracellular Ca(2+) and reactive oxygen species (ROS) and affecting associated enzymes and genes.

TL;DR: A series of DHAA thiourea derivatives containing bisphosphonate moiety exhibited potent anti-tumor activities against the SK-OV-3, BEL-7404, A549, HCT-116 and NCI-H460 tumor cell lines in vitro and proved a promising inducer of apoptosis that follows both of the mitochondria dependent pathway and the death receptor-mediated pathway.

TL;DR: Several rhein α-aminophosphonates conjugates (5a-5q) were synthesized and evaluated for in vitro cytotoxicity against HepG- 2, CNE, Spca-2, Hela and Hct-116 cell lines and indicated that 5i showed moderate ability to interact ct-DNA.

TL;DR: In this article, the EtOH extract of Euphorbia sieboldiana led to the isolation of four new oleanane-type triterpenoids, (1β,2α,3β,19β)-1,2,3,19,19-tetrahydroxyolean-12-en-28-oic acid.