Z
Zhi Yang Lai
Researcher at Taipei Medical University Hospital
Publications - 3
Citations - 208
Zhi Yang Lai is an academic researcher from Taipei Medical University Hospital. The author has contributed to research in topics: Xanthine oxidase & Surface plasmon resonance. The author has an hindex of 3, co-authored 3 publications receiving 178 citations. Previous affiliations of Zhi Yang Lai include Taipei Medical University.
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Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities
Hsiu Chen Lin,Shin Hui Tsai,Chien Shu Chen,Yuan Ching Chang,Yuan Ching Chang,Chi Ming Lee,Zhi Yang Lai,Zhi Yang Lai,Chun Mao Lin +8 more
TL;DR: The hypoxanthine/XO reaction in the DMPO-ESR technique was used to assess the combined effect on enzyme inhibition and ROS suppression by these coumarins, and the results showed that esculetin was the most potent agent among the tested compounds.
Journal ArticleDOI
Hydrophilic ester-bearing chlorogenic acid binds to a novel domain to inhibit xanthine oxidase
Shwu Huey Wang,Chien Shu Chen,Shih Hao Huang,Szu Hsu Yu,Zhi Yang Lai,Sheng-Tung Huang,Chun Mao Lin +6 more
TL;DR: Structural-based molecular modeling was performed to account for the different binding characteristics of the hydrophobic and hydrophilic esters of caffeic acid and provides the basis for interactions of caffeineic acid analogues with XO via various binding domains.
Journal ArticleDOI
Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors
Hsiang Ping Tsai,Li Wei Lin,Zhi Yang Lai,Jui Yu Wu,Chiao En Chen,Jaulang Hwang,Chien Shu Chen,Chun Mao Lin +7 more
TL;DR: TopI immobilized on the chip retained its bioactivities of DNA binding and catalysis of intermediates of the DNA- topoisomerase I complex, which provides DNA-TopI binders for interaction and primary screening with a label-free method.