Zhijun Duan

TL;DR: A method to globally capture intra- and inter-chromosomal interactions is developed and applied to generate a map at kilobase resolution of the haploid genome of Saccharomyces cerevisiae, which recapitulates known features of genome organization, thereby validating the method, and identifies new features.

TL;DR: This proof of concept method uses sciHi-C data to separate cells by karyotypic and cell-cycle state differences and identify cell-to-cell heterogeneity in mammalian chromosomal conformation.

TL;DR: It is shown by chromatin immunoprecipitation, gel shift, reporter assays and elevated expression of ELA2 in vivo in neutropenic individuals that GFI1 represses ELA1, linking these two genes in a common pathway involved in myeloid differentiation.

TL;DR: Genetic evaluation of other forms of neutropenia in humans and model organisms has helped to illuminate the role of NE, suggesting that there might be a convergent pathogenic mechanism focusing on NE.

TL;DR: A novel Hi-C method is applied to map allelic chromatin contacts of the mouse inactive X chromosome to discover a specific bipartite organization that probably plays an important role in maintenance of gene silencing.