Z
Zhiyong Zhang
Researcher at Hebei Medical University
Publications - 11
Citations - 129
Zhiyong Zhang is an academic researcher from Hebei Medical University. The author has contributed to research in topics: Liquid chromatography–mass spectrometry & Sophoricoside. The author has an hindex of 6, co-authored 8 publications receiving 106 citations.
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LC-MS/MS determination and pharmacokinetic study of seven flavonoids in rat plasma after oral administration of Cirsium japonicum DC. extract.
TL;DR: This is the first research on the pharmacokinetic study of bioactive components in rat plasma after oral administration of Cirsium japonicum DC, and the results provided a meaningful basis for better understanding the absorption mechanism of this herb medicine.
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Pharmacokinetic and excretion study of three secoiridoid glycosides and three flavonoid glycosides in rat by LC-MS/MS after oral administration of the Swertia pseudochinensis extract.
Ning Sheng,Xuran Zhi,Lin Yuan,Zhiyong Zhang,Peipei Jia,Xiaoxu Zhang,Lantong Zhang,Xinguo Wang +7 more
TL;DR: This is the first report on pharmacokinetic and excretion study of Swertia pseudochinensis extract after oral administration and provided a meaningful basis for the clinical application of this herb.
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Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of sweroside in rats.
Ning Sheng,Lin Yuan,Xuran Zhi,Cheng Cui,Zhiyong Zhang,Peipei Jia,Xiaoxu Zhang,Lantong Zhang,Xinguo Wang +8 more
TL;DR: In this paper, a high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) was developed and validated for the quantification of sweroside in rat plasma, tissue and excretion.
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Qualitative and quantitative determination of 15 main active constituents in Fructus Sophorae pill by liquid chromatography tandem mass spectrometry
TL;DR: A sensitive and specific assay for the determination of the 15 active constituents of Fructus Sophorae pill, one of the traditional Chinese medicine, was widely used for hemorrhoids, hypertension and odontalgia, indicated that the analytical method was rapid, reliable, simple and suitable for the quality evaluation.
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Investigating the in vitro stereoselective metabolism of m-nisoldipine enantiomers: characterization of metabolites and cytochrome P450 isoforms involved.
TL;DR: The in vitro metabolism of m-nisoldipine enantiomers was investigated in rat liver microsomes by the combination of two liquid chromatography mass spectrometric techniques for the first time, and it was demonstrated that (+)-m-nis oldipine is more metabolically stable than (-)-m