Zhizheng Wang

TL;DR: Ru1085 as mentioned in this paper is a metal-based metallacycle with an excitation at 808 nm and emission over 1000 nm, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity.

TL;DR: This study reports the cryogenic electron microscopy structure of a blue-light-activated CRY2 tetramer at a resolution of 3.1 Å, which shows how the CRY1 tetramer assembles and provides insights into blue- light-mediated activation ofCRY2 and a theoretical basis for developing regulators of CRYs for optogenetic manipulation.

TL;DR: A comprehensive web platform KinaFrag is constructed for the fragment-based kinase inhibitor discovery to overcome resistance, and YT9 shows promising antiproliferative against tumor cells in vitro and effectively inhibits tumor growth in vivo for wild type TRK and TRK mutants.

TL;DR: In this article , a series of macrocycle-based HPK1 inhibitors via a conformational constraint strategy was designed to achieve a higher selectivity to GLK, an HPK homology protein as a positive regulator of T-cell activation.

TL;DR: In this paper , a machine learning model was developed to identify non-bioavailable substructures based on their molecular properties and shows the accuracy of 83.5% in rats by replacing the non-available substructure of approved drug vilazodone.