Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications
TLDR
Ru1085 as mentioned in this paper is a metal-based metallacycle with an excitation at 808 nm and emission over 1000 nm, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity.Abstract:
Although Ru(II)-based agents are expected to be promising candidates for substituting Pt-drug, their in vivo biomedical applications are still limited by the short excitation/emission wavelengths and unsatisfactory therapeutic efficiency. Herein, we rationally design a Ru(II) metallacycle with excitation at 808 nm and emission over 1000 nm, namely Ru1085, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity. In vitro studies indicate that Ru1085 exhibits prominent cell uptake and desirable anticancer capability against various cancer cell lines, especially for cisplatin-resistant A549 cells. Further studies reveal Ru1085 induces mitochondria-mediated apoptosis along with S and G2/M phase cell cycle arrest. Finally, Ru1085 shows precise NIR-II fluorescence imaging guided and long-term monitored chemo-phototherapy against A549 tumor with minimal side effects. We envision that the design of long-wavelength emissive metallacycle will offer emerging opportunities of metal-based agents for in vivo biomedical applications. read more
Citations
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Long wavelength–emissive Ru(II) metallacycle–based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment
Yuling Xu,Chonglu Li,Xin L. Ma,Wei-Cherng Tuo,Le Tu,Xiaopeng Li,Yan Sun,Peter J. Stang,Yao Sun +8 more
TL;DR: An emissive Ru(II) metallacycle (herein referred to as 1) that is excited by 808-nm laser and emits at a wavelength of ∼1,000 nm via coordination-driven self-assembly is presented, broads the applications of supramolecular photosensitizers through the strategy of lengthening their wavelengths.
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Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization
Yuling Xu,Chonglu Li,Jusung An,Xin L. Ma,Jingfang Yang,Lishi Luo,Yun Deng,Jong Seung Kim,Yao Sun +8 more
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Fluorination Enhances NIR‐II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging‐Guided Cancer Therapy
Chunbin Li,Guoyu Jiang,Jia Yu,Weiwei Ji,Lingshuang Liu,Pengfei Zhang,Jian Du,Chuanlang Zhan,Jianguo Wang,B. Tang +9 more
TL;DR: In this paper , a fluorination strategy for designing A-D-A type PTAs with synchronously improved QY and photothermal conversion efficiency was proposed, and the molar extinction coefficient (ε), NIR-II QY, and PCE of all fluorinated PTAs nanoparticles (NPs) are definitely improved compared with the chlorinated counterparts.
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Construction of Long‐Wavelength Emissive Organic Nanosonosensitizer Targeting Mitochondria for Precise and Efficient In Vivo Sonotherapy
Xiangqian Zhang,Chonglu Li,Yi Zhang,Xiaofang Guan,Longcan Mei,Huili Feng,Jie Li,Le Tu,Guo-qin Feng,Ganzhen Deng,Yao Sun +10 more
TL;DR: A long‐wavelength emissive and mitochondria‐targeted organic nanosonosensitizer, named CCNU980 nanoparticles (NPs), is rationally designed, which possesses deep‐tissue optical penetration, depth‐activated ROS production, high photostability, and low phototoxicity.
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Engineering of BODIPY-based theranostics for cancer therapy
TL;DR: In this article , a review of BODIPY-based theranostics for tumor therapy is presented, with the aim of promoting the use of the theranostic in the clinical transformation of cancer therapy.
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