Z
Zhuolin Han
Researcher at Washington University in St. Louis
Publications - 7
Citations - 267
Zhuolin Han is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Clostridium difficile & Internal medicine. The author has an hindex of 5, co-authored 5 publications receiving 240 citations.
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Journal ArticleDOI
Impact of Clinical Symptoms on Interpretation of Diagnostic Assays for Clostridium difficile Infections
Erik R. Dubberke,Zhuolin Han,Linda D. Bobo,Tiffany Hink,Brenda Lawrence,Susan Copper,Joan Hoppe-Bauer,Carey-Ann D. Burnham,William Michael Dunne +8 more
TL;DR: In this paper, the authors measured how including patient presentation with the C. difficile assay result impacted assay performance to diagnose CDI and found that clinical presentation is important when interpreting C.difficile diagnostic assays.
Journal ArticleDOI
MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation.
Linda D. Bobo,Rana E. El Feghaly,Yee-Shiuan Chen,Erik R. Dubberke,Zhuolin Han,Alexandra H. Baker,Jinmei Li,Carey-Ann D. Burnham,David B. Haslam +8 more
TL;DR: It is found that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines, suggesting that toxin-induced cytoskeleton disruption is the trigger for kinase-dependent cytokine response.
Journal ArticleDOI
Mycoplasma pneumoniae periprosthetic joint infection identified by 16S ribosomal RNA gene amplification and sequencing: a case report.
TL;DR: A case of a periprosthetic joint infection in a thirty-year-old woman with juvenile rheumatoid arthritis (JRA) and hypogammaglobulinemia, who developed septic arthritis after prolonged pneumonia, is described.
Impact of clinical symptoms on interpretation of diagnostic assays for Clostridium diffic ile infections
TL;DR: Clinical presentation is important when interpreting C. difficile diagnostic assays, and different reference standards impact the sensitivity, specificity, and positive and negative predictive values of the assays to diagnose CDI.
Journal ArticleDOI
A Clostridium difficile infection “intervention”: Change in toxin assay results in fewer C difficile infection cases without changes in patient outcomes
Zhuolin Han,Kathleen M. McMullen,Anthony J. Russo,Susan Copper,David K. Warren,Erik R. Dubberke +5 more
TL;DR: There was no difference in mortality between the 2 periods, suggesting that the decreased incidence was due to increased assay specificity, not decreased sensitivity, and the new EIA resulted in fewer positive tests and reduced anti-CDI therapy.