Z
Zohra Rahmani
Researcher at Centre national de la recherche scientifique
Publications - 27
Citations - 1011
Zohra Rahmani is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Chromosome 21 & Medicine. The author has an hindex of 11, co-authored 18 publications receiving 973 citations. Previous affiliations of Zohra Rahmani include Necker-Enfants Malades Hospital.
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Journal ArticleDOI
Molecular mapping of twenty-four features of Down syndrome on chromosome 21.
Jean-Maurice Delabar,D. Théophile,Zohra Rahmani,Zoubida Chettouh,Jean-Louis Blouin,Marguerite Prieur,Bernard Noel,Pierre-Marie Sinet +7 more
TL;DR: The complex phenotype that constitutes Down syndrome may in large part simply result from the overdosage of only one or a few genes within the DCR and/or region D21S55-MX1.
Journal ArticleDOI
Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.
Zohra Rahmani,Jean-Louis Blouin,N Creau-Goldberg,P C Watkins,J F Mattei,M. Poissonnier,M Prieur,Zoubida Chettouh,A. Nicole,A Aurias +9 more
TL;DR: The size of the common duplicated region, localized on the proximal part of 21q22.3, is suspected to contain genes the overexpression of which is crucial in the pathogenesis of Down syndrome.
Journal ArticleDOI
Mapping of the down syndrome phenotype on chromosome 21 at the molecular level
Pierre-Marie Sinet,D. Théophile,Zohra Rahmani,Zoubida Chettouh,Jean-Louis Blouin,Marguerite Prieur,B. Noel,Jean-Maurice Delabar +7 more
TL;DR: The results indicate that duplication of a relatively small region of chromosome 21 plays a critical role in the pathogenesis of the Down's phenotype.
Journal ArticleDOI
Separating the spindle, checkpoint, and timer functions of BubR1
TL;DR: The BubR1 kinase domain controls spindle attachment to the kinetochores, whereas the KEN domain regulates activation of the spindle assembly checkpoint.
Journal ArticleDOI
Down syndrome critical region around D21S55 on proximal 21q22.3.
Zohra Rahmani,Jean-Louis Blouin,N. Créau-Goldberg,Paul C. Watkins,Jean-François Mattei,Marc Poissonnier,Marguerite Prieur,Zoubida Chettouh,Annie Nicole,Alain Aurias,Pierre-Marie Sinet,Jean-Maurice Delabar +11 more
TL;DR: Assessment of the copy number of five chromosome 21 sequences has shown that D21S55 was duplicated in both cases, and this region, located on the proximal part of 21q22.3, is postulated to contain genes the overexpression of which plays a major role in the pathogenesis of Down syndrome.