Z
Zoubida Chettouh
Researcher at Centre national de la recherche scientifique
Publications - 20
Citations - 1084
Zoubida Chettouh is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Chromosome 21 & Trisomy. The author has an hindex of 12, co-authored 19 publications receiving 1052 citations. Previous affiliations of Zoubida Chettouh include Necker-Enfants Malades Hospital.
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Journal ArticleDOI
Molecular mapping of twenty-four features of Down syndrome on chromosome 21.
Jean-Maurice Delabar,D. Théophile,Zohra Rahmani,Zoubida Chettouh,Jean-Louis Blouin,Marguerite Prieur,Bernard Noel,Pierre-Marie Sinet +7 more
TL;DR: The complex phenotype that constitutes Down syndrome may in large part simply result from the overdosage of only one or a few genes within the DCR and/or region D21S55-MX1.
Journal ArticleDOI
Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.
Zohra Rahmani,Jean-Louis Blouin,N Creau-Goldberg,P C Watkins,J F Mattei,M. Poissonnier,M Prieur,Zoubida Chettouh,A. Nicole,A Aurias +9 more
TL;DR: The size of the common duplicated region, localized on the proximal part of 21q22.3, is suspected to contain genes the overexpression of which is crucial in the pathogenesis of Down syndrome.
Journal Article
Molecular mapping of 21 features associated with partial monosomy 21: involvement of the APP-SOD1 region.
Zoubida Chettouh,M. F. Croquette,Bruno Delobel,S Gilgenkrants,C Leonard,C Maunoury,Marguerite Prieur,M O Rethoré,P M Sinet,M Chery +9 more
TL;DR: In this paper, the authors compared the phenotypes, karyotypes, and molecular data for six cases of partial monosomy 21, and defined regions of chromosome 21, the deletion of which corresponds to particular features of monoSomy 21.
Journal ArticleDOI
Mapping of the down syndrome phenotype on chromosome 21 at the molecular level
Pierre-Marie Sinet,D. Théophile,Zohra Rahmani,Zoubida Chettouh,Jean-Louis Blouin,Marguerite Prieur,B. Noel,Jean-Maurice Delabar +7 more
TL;DR: The results indicate that duplication of a relatively small region of chromosome 21 plays a critical role in the pathogenesis of the Down's phenotype.
Journal Article
No significant effect of monosomy for distal 21q22.3 on the Down syndrome phenotype in "mirror" duplications of chromosome 21.
Constantinos Pangalos,D Théophile,P M Sinet,A Marks,D Stamboulieh-Abazis,Zoubida Chettouh,Marguerite Prieur,C Verellen,M O Rethoré,Jérôme Lejeune +9 more
TL;DR: Three Down syndrome patients for whom karyotypic analysis showed a "mirror" (reverse tandem) duplication of chromosome 21 were studied, suggesting that the reverse tandem chromosomes did not result from a telomeric fusion between chromosomes 21 but from a translocation between sister chromatids.